Fluticasone-Salmeterol Side Effects

Possible side effects of fluticasone-salmeterol are listed below. Call your doctor for medical advice if they are severe or last more than a few days.

• Sneezing and/or runny nose
• Throat irritation and/or sore throat 
• Headache
• Sinus pain
• Stomach pain, nausea, vomiting, diarrhea
• Muscle pain or bone pain
• Tooth pain
• Weakness and/or fatigue
• Dizziness
• Excessive sweating
• Uncontrolled shaking
• Sleep difficulties

Fluticasone-salmeterol can also cause more serious side effects and allergic reactions. Call your doctor right away or seek emergency medical attention if the following effects occur:

• Skin rash, hives, itching (allergic reaction)
• Swelling in the eyes, face, lips, tongue, throat, hands, lower legs, ankles, or feet
• Worsening wheezing, coughing, or chest tightness after inhaling fluticasone-salmeterol
• Noisy breathing
• Chest pain
• Pounding or irregular heartbeat
• Choking or difficulty swallowing
• Hoarseness
• White patches inside your mouth
• Tingling or burning in the hands or feet
• Fainting
• Fever, chills, or other signs of an upper respiratory tract infection 

The above list may not include all the potential side effects of fluticasone-salmeterol. Contact your healthcare provider if your side effects are unusual or severe or they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Fluticasone-salmeterol Overdose: In case of an overdose of fluticasone-salmeterol, call your doctor immediately. You can also call your local poison control center, provincial poison control center, or the national poison control center at 1-800-222-1222. Call 911 or emergency services if a person has collapsed, cannot breathe, has had a seizure, or cannot be awakened. Signs and symptoms of an overdose may include convulsions, chest pain, a fast, pounding or irregular heartbeat, headache, dizziness, fainting, blurred vision, nervousness, uncontrolled shaking, muscle weakness, muscle cramps, nausea, fatigue, lack of energy, dry mouth, and sleep difficulties.

Source: FDA