Do not take this medication with any of the following medications:

-cidofovir
-eplerenone
-tranylcypromine
This medication may also interact with the following medications:

-aspirin
-certain medicines for blood pressure or heart disease like benazepril, lisinopril, losartan, valsartan
-certain medicines that treat or prevent blood clots like heparin and enoxaparin
-cholestyramine
-cyclosporine
-digoxin
-lithium
-medicines that relax muscles for surgery
-NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
-other diuretics
-potassium salts or supplements
-steroid medicines like prednisone or cortisone
-trimethoprim

They need to know if you have any of these conditions:

-Addison''s disease or low adrenal gland function
-high levels of potassium in the blood
-kidney disease
-liver disease
-an unusual or allergic reaction to spironolactone, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care provider for regular checks on your progress. Check your blood pressure as directed. Ask your health care provider what your blood pressure should be. Also, find out when you should contact him or her.
Do not treat yourself for coughs, colds, or pain while you are using this medicine without asking your health care provider for advice. Some medicines may increase your blood pressure.
Check with your health care provider if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medicine.
You may need to be on a special diet while taking this medicine. Ask your health care provider. Also, find out how many glasses of fluid you need to drink each day.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effects of this medicine. Avoid alcoholic drinks.
Avoid salt substitutes unless you are told otherwise by your health care provider.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put into the trash, pour the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.