Do not take this medicine with any of the following medications:

-MAOIs like Marplan, Nardil, and Parnate
-reserpine
-tetrabenazine

This medicine may also interact with the following medications:

-alcohol
-droperidol
-entacapone
-iron supplements or multivitamins with iron
-isoniazid, INH
-linezolid
-medicines for depression, anxiety, or psychotic disturbances
-medicines for high blood pressure
-medicines for sleep
-metoclopramide
-papaverine
-procarbazine
-tedizolid
-rasagiline
-selegiline
-tolcapone

They need to know if you have any of these conditions:

-diabetes
-drink alcohol
-glaucoma
-heart disease
-high blood pressure
-history of irregular heartbeat
-kidney disease
-liver disease
-low blood pressure
-lung or breathing disease, like asthma
-mood or behavior changes
-narcolepsy
-sleep apnea
-stomach or intestine problems
-suicidal thoughts, plans or attempt; a previous suicide attempt by you or a family member
-an unusual or allergic reaction to levodopa, carbidopa, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care professional for regular checks on your progress. Tell your health care professional if your symptoms do not start to get better or if they get worse. Do not stop taking except on your health care professional''s advice. You may develop a severe reaction. Your health care professional will tell you how much medicine to take.

Talk to your healthcare provider about what you need to do to care for your PEG-J tube site. Watch for signs of infection. Complications in the stomach or intestines can occur from the PEG-J tube procedure. Contact your healthcare provider immediately if you experience stomach pain, constipation that does not go away, nausea, vomiting, fever, or black stools.

If your PEG-J tube becomes kinked, knotted, or blocked, this may cause your Parkinson''s symptoms to worsen or cause recurring movement problems (motor fluctuations). Call your healthcare provider if your Parkinson''s symptoms get worse or you have slow movement while you are treated with this medicine.

Eating high protein foods may affect how this medicine works. Tell your healthcare provider if you change your diet.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

When taking this medicine, you may fall asleep without notice. You may be doing activities like driving a car, talking, or eating. You may not feel drowsy before it happens. Contact your health care provider right away if this happens to you.

There have been reports of increased sexual urges or other strong urges such as gambling while taking this medicine. If you experience any of these while taking this medicine, you should report this to your health care provider as soon as possible.

Patients and their families should watch out for new or worsening depression or thoughts of suicide. Call your healthcare provider right away if you feel depressed or have thoughts of suicide.

You may experience a ''wearing off'' effect before the time for your next dose of this medicine. You may also experience an ''on-off'' effect where the medicine apparently stops working for any time from a minute to several hours, then suddenly starts working again. Tell your doctor or health care professional if any of these symptoms happen to you. Your dose may need adjustment.

If you have diabetes, you may get a false-positive result for sugar in your urine. Check with your doctor or health care professional.

This medicine may discolor the urine or sweat, making it look darker or red in color. This is of no cause for concern. However, this may stain clothing or fabrics.

This medicine may cause a decrease in vitamin B6. You should make sure that you get enough vitamin B6 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Keep out of the reach of children.

Store unopened cassettes in the refrigerator between 2 degrees C and 8 degrees C (36 degrees F to 46 degrees F). Do not freeze. Protect the cassette from light and keep it in the carton before using. Use before the expiration date printed on the cassette. Throw away any expired medicine.

Once a carton is removed from the refrigerator, opened, or in use, discard after 16 hours, even if it contains medication. Use before the expiration date printed on the cassette.