This medicine may interact with the following medications:

-aliskiren
-ambrisentan
-boceprevir
-carbamazepine
-clarithromycin
-colchicine
-conivaptan
-dabigatran
-digoxin
-everolimus
-fexofenadine
-grapefruit juice
-imatinib
-indinavir
-irinotecan
-itraconazole
-ketoconazole
-lapatinib
-lopinavir/ritonavir
-maraviroc
-medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
-methotrexate
-mitoxantrone
-nefazodone
-nelfinavir
-nilotinib
-phenytoin
-posaconazole
-ranolazine
-rifampin
-ritonavir
-rosuvastatin
-saquinavir
-St. John''s Wort
-sulfasalazine
-telaprevir
-telithromycin
-topotecan
-voriconazole

They need to know if you have any of these conditions:

-bleeding disorders
-blood clots
-diabetes (high blood sugar)
-having or recent surgery
-heart attack
-heart disease
-heart failure
-high blood pressure
-high cholesterol
-irregular heartbeat or rhythm
-liver disease
-pancreatitis
-stroke
-an unusual or allergic reaction to ponatinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.
Your vision may be tested before and during use of this medicine. Tell your health care provider right away if you have any change in your eyesight.
Before having surgery, talk to your health care provider to make sure it is ok. This medicine can increase the risk of poor healing of your surgical site or wound. You will need to stop this medicine for 7 days before surgery. After surgery, wait at least 2 weeks before restarting this medicine. Make sure the surgical site or wound is healed enough before restarting this medicine. Talk to your health care provider if questions.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
This medicine may increase your risk of getting an infection. Call your health care provider for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
Do not become pregnant while taking this medicine or for 3 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 6 days after stopping it.

Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.