Do not take this medicine with any of the following medications:

-certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
-certain medicines for seizures like carbamazepine, oxcarbazepine, phenobarbital, phenytoin
-certain medicines for stomach problems like esomeprazole, pantoprazole, omeprazole, lansoprazole, rabeprazole
-cisapride
-dexamethasone
-dofetilide
-dronedarone
-lumacaftor; ivacaftor
-pimozide
-rifampin
-rifapentine
-St. John''s wort; Hypericum perforatum
-thioridazine
-ziprasidone

This medicine may also interact with the following medications:

-buffered medicines, like buffered aspirin
-calcium supplements
-certain antibiotics like clarithromycin, erythromycin, telithromycin, troleandomycin, rifabutin
-certain medicines for stomach problems like aluminum hydroxide, magnesium hydroxide, calcium carbonate, cimetidine, famotidine, nizatidine, ranitidine
-iron supplements
-metformin
-methadone
-other antiviral medicines for HIV or AIDS
-other medicines that prolong the QT interval (cause an abnormal heart rhythm)
-sucralfate

They need to know if you have any of these conditions:

-liver disease
-suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
-an unusual or allergic reaction to dolutegravir, rilpivirine, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care provider for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care provider or pharmacist for more information.

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.