Do not take this medicine with any of the following medications:

-certain medicines for fungal infections like itraconazole, ketoconazole, posaconazole, voriconazole
-certain medicines for irregular heart beat like bepridil, bretylium, dronedarone, quinidine
-cisapride
-halofantrine
-mesoridazine
-pimozide
-rasagiline
-selegiline
-thioridazine
This medicine may also interact with the following medications:

-alcohol
-antihistamines for allergy, cough and cold
-antiviral medicines for HIV or AIDS
-arsenic trioxide
-atropine
-certain antibiotics like clarithromycin, erythromycin, gemifloxacin, levofloxacin, moxifloxacin, ofloxacin, pentamidine, telithromycin, rifampin, rifapentine
-certain medicines for anxiety or sleep
-certain medicines for bladder problems like oxybutynin, tolterodine
-certain medicines for cancer like dasatinib, lapatinib, sunitinib, vorinostat
-certain medicines for depression like amitriptyline, desipramine, fluoxetine, sertraline
-certain medicines for irregular heart beat like amiodarone, disopyramide, flecainide, procainamide, propafenone, sotalol
-certain medicines for malaria like chloroquine, mefloquine
-certain medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
-certain medicines for nausea or vomiting like dolasetron, droperidol, granisetron, ondansetron
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin, primidone
-certain medicines for stomach problems like dicyclomine, hyoscyamine
-certain medicines for travel sickness like scopolamine
-certain medicines for Parkinson''s disease like benztropine, trihexyphenidyl
-fluconazole
-general anesthetics like halothane, isoflurane, methoxyflurane, propofol
-haloperidol
-ipratropium
-linezolid
-local anesthetics like lidocaine, pramoxine, tetracaine
-MAOIs like Marplan, Nardil, and Parnate
-medicines that relax muscles for surgery
-methylene blue
-octreotide
-other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide, ziprasidone
-other narcotic medicines for pain or cough
-peginterferon alfa-2b
-phenothiazines like chlorpromazine, prochlorperazine
-ranolazine
-tacrolimus
-vardenafil

They need to know if you have any of these conditions:

-brain tumor
-drug abuse or addiction
-head injury
-heart disease
-if you often drink alcohol
-kidney disease
-liver disease
-low adrenal gland function
-low blood pressure
-lung, asthma, or breathing problems
-mental health disease
-seizures
-stomach or intestine problems
-taken an MAOI such as Marplan, Nardil, or Parnate in the last 14 days
-thyroid disease
-an unusual or allergic reaction to methadone, other opioid analgesics, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider regularly. If you are using this medicine for pain, tell your health care provider if your pain does not go away, if it gets worse, or if you have new or a different type of pain. If you are using this medicine for opioid use disorder, attend counseling or support groups that your health care provider recommends. Do not try to overcome the effects of the medicine by taking large amounts of narcotics. This can cause severe problems including death. Also, you may be more sensitive to lower doses of narcotics after you stop taking this medicine.
Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. Your health care provider will tell you how much medicine to take. If your health care provider wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.
If you take other medicines that also cause drowsiness like other narcotic pain medicines, benzodiazepines, or other medicines for sleep, you may have more side effects. Give your health care provider a list of all medicines you use. He or she will tell you how much medicine to take. Do not take more medicine than directed. Get emergency help right away if you have trouble breathing or are unusually tired or sleepy.
Talk to your health care provider about naloxone and how to get it. Naloxone is an emergency medicine used for an opioid overdose. An overdose can happen if you take too much opioid. It can also happen if an opioid is taken with some other medicines or substances, like alcohol. Know the symptoms of an overdose, like trouble breathing, unusually tired or sleepy, or not being able to respond or wake up. Make sure to tell caregivers and close contacts where it is stored. Make sure they know how to use it. After naloxone is given, you must get emergency help right away. Naloxone is a temporary treatment. Repeat doses may be needed.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage regimens.
This medicine will cause constipation. If you do not have a bowel movement for 3 days, call your health care provider.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your health care provider if the problem does not go away or is severe.
Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your doctor about the benefits and risks of breast-feeding while using this medicine. This medicine does pass into breast milk. Talk to your doctor if you plan to begin or stop using this medicine while breast-feeding or if you plan to stop breast-feeding.

Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.
Store Methadose at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not freeze. Protect from light. Keep container tightly closed.
Store methadone hydrochloride oral solution and oral concentrate (Methadone Intensol) at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed.
This medicine may cause harm and death if it is taken by other adults, children, or pets. Return medicine that has not been used to an official disposal site. Contact the DEA at 1-800-882-9539 or your city/county government to find a site. If you cannot return the medicine, flush it down the toilet. Do not use the medicine after the expiration date.