What side effects may I notice from receiving Methotrexate Sodium?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-back pain
-breathing problems or shortness of breath
-confusion
-diarrhea
-dry, nonproductive cough
-low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk of infections and bleeding
-mouth sores
-redness, blistering, peeling or loosening of the skin, including inside the mouth
-seizures
-severe headaches
-signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
-signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
-signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like
symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
-stiff neck
-vomiting
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

-dizziness
-hair loss
-headache
-stomach pain
-upset stomach

This list may not describe all possible side effects for Methotrexate Sodium. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.