Ondansetron

Medically Reviewed by HaVy Ngo, Pharm.D.

Last Reviewed: Jun 15, 2022

Common Questions


Common Questions about ondansetron hydrochloride (Zofran)


Can ondansetron or Zofran be used for anxiety?
Ondansetron (Zofran) is not indicated to treat anxiety. However, some people feel less anxious when their nausea and vomiting are under control. 


Does ondansetron make you drowsy or sleepy?
Yes, ondansetron can make you drowsy or sleepy. You should be very careful if you have to drive or perform activities that require mental alertness, especially at the beginning of therapy when you don’t know how your body would react to this medication.


How long before a meal should I take ondansetron?
If you take ondansetron to prevent nausea and vomiting when you eat, you should take the regular oral tablet about 30 minutes to an hour before meals. For the orally disintegrating tablet or oral soluble film, you can take them about 15 minutes before meals.


When should I expect the effects of ondansetron?
The effects of ondansetron can last from 8 to 12 hours. Ondansetron works pretty quickly. You may experience some relief as soon as 30 minutes after taking it.


What is the price of Ondansetron without insurance?

Without insurance, Ondansetron can be as high as $135.99 (generic), but with a free BuzzRx prescription discount coupon, you could pay as low as $16.07 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not. 



What is the price of Ondansetron with insurance?

Ask your pharmacist or insurance provider for your copay price on Ondansetron—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins. You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for ondansetron. When using the BuzzRx lookup tool to find the price of your medication, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not.