Ondansetron

Medically Reviewed by HaVy Ngo, Pharm.D.

Last Reviewed: Jun 15, 2022

Drug Details


Common Brands:

Zofran, Zofran ODT

Availability:

Prescription only

Therapeutic Class:

5-HT3 receptor antagonist / antiemetic

Forms:

Ondansetron regular tablet: 
4 mg |  8 mg | 24 mg

Ondansetron oral soluble film: 
4 mg | 8 mg

Ondansetron orally 
disintegrating tablets: 
4 mg | 8 mg

Ondansetron oral solution: 
4 mg / 5mL

Intravenous ondansetron:
2 mg/mL

Administration:

By mouth - this medication guide will focus on the oral dosage form of ondansetron. 

IV administration (into a vein)

Therapeutic Uses:

Prevents nausea and vomiting caused by surgery, cancer chemotherapy, or radiation treatment.

Controlled Status:

Not a controlled substance


What is ondansetron hydrochoride (Zofran)?

Ondansetron is the generic name of Zofran. Ondansetron is a commonly-used antiemetic both in the hospital and outpatient. Ondansetron is used to prevent nausea and vomiting caused by surgery, cancer chemotherapy, or radiation treatment. Ondansetron is used alone or in combination with other medications. 

There may be other uses of ondansetron hydrochloride—your pharmacist or physician can give you further information and assistance. Doctors also prescribe ondansetron for morning sickness. However, the use of ondansetron for morning sickness is controversial due to its potential for causing birth defects.

Who can take ondansetron hydrochoride (Zofran)?

  • Adults
  • Children who are at least four years old