Do not take this medicine with any of the following medications:

-defibrotide

This medicine may also interact with the following medications:

-amiodarone
-aspirin and aspirin-like medicines
-certain antibiotics like azithromycin, clarithromycin, and erythromycin
-certain medicines for fungal infections like ketoconazole and itraconazole
-certain medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
-cyclosporine
-dronedarone
-NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
-quinidine
-rifampin
-SSRIs, medicines for depression, like citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline
-SNRIs, medicines for depression, like desvenlafaxine, duloxetine, levomilnacipran, venlafaxine
-verapamil

They need to know if you have any of these conditions:

-antiphospholipid antibody syndrome
-artificial heart valve
-bleeding disorders
-bleeding in the brain
-blood in your stools (black or tarry stools) or if you have blood in your vomit
-cancer in the stomach or intestines
-history of blood clots
-history of stomach bleeding
-mechanical heart valve
-kidney disease
-liver disease
-recent injury, recent or planned surgery or procedure
-recent or planned spinal or epidural procedure
-take medicines that treat or prevent blood clots
-an allergic reaction to edoxaban, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your healthcare professional for regular checks on your progress. You may need blood work done while you are taking this medicine. Your condition will be monitored carefully while you are receiving this medicine. It is important not to miss any appointments.

Avoid sports and activities that might cause injury while you are using this medicine. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your healthcare professional.

If you are going to need surgery or other procedure, tell your healthcare professional that you are taking this medicine.

Wear a medical ID bracelet or chain. Carry a card that describes your disease and details of your medicine and dosage times.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.