Do not take this medicine with any of the following medications:

-certain antibiotics like clarithromycin, erythromycin, telithromycin
-grapefruit juice
-medicines for fungal infections like itraconazole, ketoconazole, posaconazole, voriconazole
-mifepristone, RU-486
-rifabutin, rifampin

This medicine may also interact with the following medications:

-boceprevir
-bromocriptine
-carbamazepine
-cimetidine
-cisapride
-clotrimazole
-cyclosporine
-danazol
-diltiazem
-fluconazole
-indinavir
-metoclopramide
-nicardipine
-phenobarbital
-phenytoin
-rifapentine
-ritonavir
-St. John''s wort
-telaprevir
-troleandomycin
-vaccines
-verapamil

They need to know if you have any of these conditions:

-diabetes
-heart disease or heart failure
-high cholesterol or triglycerides
-infection
-liver disease
-an unusual or allergic reaction to sirolimus, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor for regular checks on your progress. You will need frequent blood checks.

This medicine can cause your cholesterol or lipid levels to go up. You may need treatment for high cholesterol.

If you get a cold or other infection while receiving this medicine, call your doctor or health care professional. Do not treat yourself. The medicine may decrease your body''s ability to fight infections.

This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.

This medicine may increase your risk of getting some cancers. Talk with your doctor.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Women who are able to have children should use effective birth control before, during, and for 12 weeks after stopping this medicine.

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.