Do not take this medicine with any of the following medications:

-riociguat
-viloxazine
This medicine may also interact with the following medications:

-allopurinol
-aminoglutethimide
-caffeine
-certain antibiotics like ciprofloxacin, enoxacin, telithromycin, erythromycin or clarithromycin
-certain medicines for blood pressure, heart disease, irregular heart beat like adenosine, mexiletine, propafenone, propranolol, verapamil
-certain medicines for sleep or anxiety
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-certain medicines used during surgery
-cimetidine
-disulfiram
-ephedrine
-estrogens or birth control pills
-fluvoxamine
-interferon alpha
-isoproterenol
-lithium
-methotrexate
-pentoxifylline
-rifampin
-St. John''s wort
-sulfinpyrazone
-thiabendazole
-ticlopidine

They need to know if you have any of these conditions:

-heart disease
-irregular heartbeat or rhythm
-liver disease
-seizures
-stomach ulcers, other stomach or intestine problems
-thyroid disease
-smoke tobacco cigarettes
-an unusual or allergic reaction to theophylline, aminophylline, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not improve or if they get worse. You may need blood work done while you are taking this medicine.
If you smoke, tell your health care provider if you notice this medicine is not working well for you. Talk to your health care provider if you decide to stop smoking.
You should make sure that you get enough vitamin B6 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care provider.

Keep out of the reach of children and pets.
Store at room temperature at 25 degrees C (77 degrees F). Protect from light. Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, pour the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.