Vitamin D3

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Feb 28, 2023

Warnings


Vitamin D3 Risks, Warnings, and Complications


Too much vitamin D can lead to adverse effects like kidney stones and kidney disease. Check with your doctor before starting vitamin D supplementation. Keep all your healthcare appointments while you are on vitamin D supplements. Get all the blood tests ordered by your doctor in a timely manner. This will ensure the conditions diagnosed by your healthcare provider are under control and you do not have high calcium or vitamin D levels. Call your doctor if you notice signs and symptoms like loss of appetite, weight loss, muscle pain, muscle stiffness, bone pain, or changes in urination.


Precautions Before Starting Vitamin D3

Tell your healthcare provider if you have ever had an allergic reaction to vitamin D3 (cholecalciferol), any of the active or inactive ingredients in vitamin D supplements, or any other medications. Your pharmacy can give you a list of ingredients in vitamin D supplements.

Give your doctor and pharmacist a complete list of your medications, including prescription drugs, over-the-counter medicines, vitamins, supplements, and herbal products. This can help avoid possible drug interactions.

Give your doctor a complete medical history. Vitamin D may not be right for people with certain medical conditions such as hyperparathyroidism (too much parathyroid hormone), hypercalcemia (high blood levels of calcium), or kidney disease.

Tell your doctor if you are pregnant, could be pregnant, plan to get pregnant, or are breastfeeding.

Precautions During Use of Vitamin D3

Keep all your healthcare appointments while taking vitamin D3 dietary supplements. Stop taking vitamin D supplementation and call your doctor if you develop loss of appetite, weight loss, muscle pain, or changes in urination. Call your doctor if you become pregnant while on vitamin D3.

Vitamin D3 Drug Interactions

Certain other medications can affect how vitamin D supplements work. Possible interactions between vitamin D3 and other drugs can increase the risk of severe adverse reactions.

The following medications may have interactions with vitamin D3:

  • Calcium supplements
  • Multivitamins
  • Anticonvulsants like carbamazepine (Teril, Equetro, others), phenobarbital, and phenytoin (Dilantin)
  • Medications used to treat high cholesterol such as cholestyramine (Prevalite)
  • Weight loss drugs like orlistat (Xenical, Alli) 
  • Steroid medicines like prednisone (Rayos)
  • Water pills (thiazide diuretics)

The above list may not include all possible interactions of vitamin D3. Give your doctor or pharmacist a complete list of your medications, including prescription drugs, OTC (non-prescription) medications, dietary supplements, and herbal remedies. Also, tell your healthcare professionals if you smoke, drink alcohol, or use recreational drugs because some of these substances can cause serious health complications when used with dietary supplements and medication.