Donepezil

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Jan 25, 2024

Pros & Cons


Donepezil (Aricept) Pros and Cons

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  • Donepezil hydrochloride is the first-choice medication for cognitive impairment related to Alzheimer’s disease.
  • You only need to take donepezil once daily at bedtime.
  • It is available as a dissolvable pill for people who have trouble swallowing pills.
  • The transdermal skin patch is convenient if you have trouble swallowing pills or remembering to take a pill every day.
  • There is a lower-cost generic available.

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  • Most patients tolerate donepezil, but it can cause nausea, vomiting, and diarrhea, especially at higher doses.
  • This medication may not be suitable for people with certain health conditions, such as seizures, lung disease, or stomach ulcers.
  • Donepezil can improve cognitive and behavioral symptoms associated with Alzheimer’s disease but does not cure the condition.