Warnings


What may interact with GAVRETO?


-certain antivirals for HIV or hepatitis
-certain medicines for fungal infections like ketoconazole, itraconazole, or posaconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-grapefruit juice

What should I tell my health care provider before I take GAVRETO?

They need to know if you have any of these conditions:

-bleeding disorders
-having surgery or recent surgery
-high blood pressure
-liver disease
-lung or breathing disease, like asthma
-scarring or thickening of the lungs
-an unusual or allergic reaction to pralsetinib, other medicines, foods, dyes or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using GAVRETO?

Visit your health care professional for regular checks on your progress. Tell your health care professional if your symptoms do not start to get better or if they get worse.
Do not become pregnant while taking this medicine or for 2 weeks after stopping it. Women should use a non-hormonal form of birth control. Women should inform their health care professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 1 week after stopping it. There is potential for serious side effects to an unborn child. Talk to your health care professional for more information. Do not breast-feed an infant while taking this medicine or for 1 week after stopping it.
This medicine may make it more difficult to get pregnant or to father a child. Talk to your health care professional if you are concerned about your fertility.
Before having surgery, talk to your health care provider to make sure it is ok. This drug can increase the risk of poor healing of your surgical site or wound. You will need to stop this drug for 5 days before surgery. After surgery, wait at least 2 weeks before restarting this drug. Make sure the surgical site or wound is healed enough before restarting this drug. Talk to your health care provider if questions.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your health care professional if the problem does not go away or is severe.
Call your health care professional for advice if you get a fever, chills, or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This medicine decreases your body''s ability to fight infections. Try to avoid being around people who are sick.
Avoid taking medicines that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your health care professional. These medicines may hide a fever.

Where should I keep my medicine?

Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.