Do not take this medicine with any of the following medications:

-atazanavir
-atazanavir; cobicistat
-darunavir
-darunavir; cobicistat
-darunavir; cobicistat; emtricitabine; tenofovir alafenamide
-delavirdine
-fosamprenavir
-tipranavir
This medicine may interact with the following medications:

-antiviral medications for HIV or AIDS
-aprepitant
-calcium channel blockers like diltiazem and verapamil
-certain antibiotics like clarithromycin, erythromycin, and troleandomycin
-certain medicines for fungal infections like fluconazole, ketoconazole, itraconazole, posaconazole, and voriconazole
-certain medicines for seizures like carbamazepine and phenytoin
-cimetidine
-ciprofloxacin
-clotrimazole
-conivaptan
-crizotinib
-cyclosporine
-digoxin
-dronedarone
-enzalutamide
-fluvoxamine
-grapefruit juice or Seville oranges
-idelalisib
-imatinib
-methotrexate
-mitotane
-nefazodone
-rifampin
-St. John''s wort
-tofisopam

They need to know if you have any of these conditions:

-bleeding disorder
-diabetes (high blood sugar)
-heart disease
-heart failure
-high blood pressure
-high cholesterol
-infection
-irregular heartbeat or rhythm
-liver disease
-recent surgery
-smoke tobacco cigarettes
-take medicines that treat or prevent blood clots
-an unusual or allergic reaction to ibrutinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

You may need blood work done while you are taking this medicine.
This medicine may increase your risk to bruise or bleed. Call your health care provider if you notice any unusual bleeding.
This medicine may increase your risk of getting an infection. Call your health care provider for advice if you get a fever, chills, or sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
If you are going to need surgery or other procedure, tell your health care provider that you are using this medicine.
Tell your dentist and dental surgeon that you are taking this medicine. You should not have major dental surgery while on this medicine. See your dentist to have a dental exam and fix any dental problems before starting this medicine. Take good care of your teeth while on this medicine. Make sure you see your dentist for regular follow-up appointments.
Talk to your health care provider about your risk of cancer. You may be more at risk for certain types of cancer if you take this medicine.
Do not become pregnant while taking this medicine or for 1 month after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 1 month after stopping it. There is a potential for serious harm to an unborn child. Talk to your health care provider for more information. Do not breast-feed an infant while taking this medicine or for 1 week after stopping it.

Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original container. Throw away any unused medicine after the expiration date.