Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Aug 13, 2024

Pros & Cons


Activella Pros and Cons

pros header.svg

  • Activella can relieve moderate to severe vasomotor symptoms of menopause.
  • It lowers your risk of fractures due to bone loss.
  • Activella includes progestin compounds which protect against endometrial cancer.
  • You only need to take Activella once daily.
  • It is available as a lower cost generic.

cons header.svg

  • Activella can increase your risk of blood clots, stroke, heart attack, breast cancer, endometrial cancer, and ovarian cancer.
  • It can cause more side effects than topical estrogen therapy (creams and gels).