Do not take this medicine with any of the following medications:

-dipyridamole
-nitrates like amyl nitrite, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin
-sildenafil
-tadalafil
-theophylline
-vardenafil

This medicine may also interact with the following medications:

-antacids
-antiviral medicines for HIV or AIDS
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-itraconazole
-ketoconazole
-rifampin
-St. John''s Wort

They need to know if you have any of these conditions:

-bleeding disorders
-heart disease
-kidney disease
-liver disease
-low blood pressure
-pulmonary hypertension associated with idiopathic interstitial pneumonias
-pulmonary veno-occlusive disease (PVOD)
-smoke tobacco
-an unusual or allergic reaction to riociguat, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor for regular check ups. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

This medicine can cause birth defects. Do not get pregnant while taking this drug. Females with child-bearing potential will need to have a negative pregnancy test before starting this medicine, every month while taking this medicine, and 1 month after stopping this medicine. Use 2 reliable forms of birth control together while you are taking this medicine and for 1 month after you stop taking this medicine. If you think that you might be pregnant talk to your doctor right away.

Because of the risks of birth defects, females can only receive this medicine through a special program. Doctors, pharmacies, and patients must meet all of the conditions of the program. Your health care provider will help you get signed up with the program if you need this medicine. Males do not need to participate in this program to receive this medicine.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.