Do not take this medicine with any of the following medications:

-gatifloxacin

This medicine may also interact with the following medications:

-alcohol
-atorvastatin
-digoxin
-female hormones, like estrogens or progestins and birth control pills
-fexofenadine
-insulin
-ketoconazole
-midazolam
-nifedipine
-ranitidine
-rifampin
-steroid medicines like prednisone or cortisone
-sulfonylureas like glimepiride, glipizide, glyburide
-thyroid medicines

They need to know if you have any of these conditions:
-bladder cancer
-diabetic ketoacidosis
-eye disease called macular edema
-heart disease
-heart failure
-kidney disease
-liver disease
-pancreatitis
-polycystic ovary syndrome
-previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat
-swelling of the arms, legs, or feet
-type 1 diabetes
-an unusual or allergic reaction to alogliptin, pioglitazone, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care professional for regular checks on your progress. You may need regular tests to make sure your liver is working properly.

A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.

Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.

Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.

Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar.

This medicine may increase your risk of having certain heart problems. Get medical help right away if you have any chest pain or tightness, or pain that radiates to the jaw or down the arm, and shortness of breath. These may be signs of a serious medical condition.

This medicine may cause ovulation in premenopausal women who do not have regular monthly periods. This may increase your chances of becoming pregnant. Talk with your doctor or health care professional about your birth control options while taking this medicine. Contact your doctor or health care professional right away if think you are pregnant.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.