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Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Oct 12, 2023

Common Questions


Common Questions about Estradiol


Is estradiol the same as estrogen?

Yes, estradiol is the most potent estrogen. It is the man-made version of the hormone that is naturally found in the body.



How long can I take estradiol for postmenopausal symptoms?

Estradiol increases your risk of serious health complications such as blood clots, heart attack, stroke, and certain cancers. You should take this medication at the lowest effective dose for the shortest possible time. Your healthcare provider will review you every 3-6 months and decide if you should continue on this medication.



Does estradiol cause weight gain?

Some people experience an increase in weight on estradiol, while others notice weight loss. Estradiol may make you feel more full and thereby control your appetite, leading to weight loss. On the other hand, estradiol can cause fluid retention and may cause some increase in weight. If weight changes are a concern, talk to your healthcare provider.



Do I need estradiol oral tablets or vaginal cream?

Whether you need estradiol oral tablets or estradiol vaginal cream/estradiol gel depends on your symptoms. If you have symptoms such as vaginal dryness or vaginal itching, your provider may recommend a topical product such as an estradiol vaginal cream or gel. On the other hand, if your symptoms are hot flashes and night sweats, you may need to take the tablet.



What to avoid when taking estradiol?

Your provider may ask you to avoid eating grapefruit and drinking grapefruit juice while on estradiol as this can lead to increased plasma concentrations of the medicine and increased side effects.



What is the price of estradiol without insurance?

Without insurance, estradiol can be as high as $226.30, but with a free BuzzRx prescription discount coupon, you could pay as low as $49.99 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescription drugs—whether you have insurance or not.



What is the price of estradiol with insurance?

Ask your pharmacist or insurance provider for your copay price on estradiol—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins.

You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for estradiol. When using the BuzzRx lookup tool to find the price of your medicine, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not.