estradiol Drug Details (Generic)
Therapeutic Class:
Estrogen replacement hormone therapy
Forms:
Tablet, Tube of cream
Administration:
By mouth, Topical
Therapeutic Uses:
Menopause symptoms such as hot flashes, vaginal dryness, irritation, itching
Prevention of osteoporosis (bone loss) in women after menopause
Estrogen replacement in women with primary ovarian failure
Controlled Status:
Not a controlled substance
What is estradiol?
Estradiol (eh struh dai ole) is a type of estrogen (female sex hormone). It is used for hormone replacement therapy in menopausal women to relieve symptoms such as hot flashes and vaginal dryness, and itching. Ethinyl estradiol is a synthetic form of estradiol usually found in oral contraceptive pills (birth control pills).
There may be other uses of estradiol - your pharmacist or physician can give you further information.
Who can use estradiol?
Estradiol is generally used in adult women. The safety and efficacy of this medication have not been established in children.
Lyllana Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Transdermal patch - Biweekly
ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.
Yuvafem Drug Details (Brand)
Generic Name:
Therapeutic Class:
Availability:
Common Brands:
Form:
Vaginal insert
Minivelle Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Transdermal patch - Biweekly
ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.
Vagifem Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Vaginal insert
ESTRADIOL (es tra DYE ole) vaginal insert is used to treat females who experience painful sexual intercourse, a symptom of menopause that occurs due to changes in and around the vagina.
Evamist Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Topical spray, solution
ESTRADIOL (es tra DYE ole) is an estrogen. It is mostly used as hormone replacement in menopausal women. This medicine helps relieve symptoms of menopause such as hot flashes, night sweats, and mood changes.
Menostar Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Transdermal patch - Weekly
ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.
Elestrin Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Topical gel
ESTRADIOL (es tra DYE ole) contains the female hormone estrogen. It is used for symptoms of menopause like hot flashes, night sweats, and mood changes. This medicine may also help relieve other symptoms like vaginal dryness, itching and increased or painful urination.
Imvexxy Starter Pack Drug Details (Brand)
Generic Name:
Therapeutic Class:
Availability:
Common Brands:
Form:
Alora Drug Details (Brand)
Therapeutic Class:
Estrogen hormone
Forms:
Tablet, topical gel, cream, and spray
Administration:
By mouth, by application to the vagina
Therapeutic Uses:
To treat menopause symptoms
To treat certain types of breast cancer and prostate cancer
To treat low estrogen levels in women with certain conditions
To prevent postmenopausal osteoporosis
Controlled Status:
Not a controlled substance
Estradiol Drug Class
Estradiol (es-trah-dye-ohl) is an estrogen hormone.
Estradiol Age Range
Estradiol is approved for use in adults. The safety and efficacy of this drug have not been established in pediatric patients.
Divigel Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Topical gel
ESTRADIOL (es tra DYE ole) contains the female hormone estrogen. It is used for symptoms of menopause like hot flashes, night sweats, and mood changes. This medicine may also help relieve other symptoms like vaginal dryness, itching and increased or painful urination.
EstroGel Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Topical gel
ESTRADIOL (es tra DYE ole) contains the female hormone estrogen. It is used for symptoms of menopause like hot flashes, night sweats, and mood changes. This medicine may also help relieve other symptoms like vaginal dryness, itching and increased or painful urination.
Estrace Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Oral tablet|Vaginal cream
ESTRADIOL (es tra DYE ole) is an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.
Estring Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Vaginal insert
ESTRADIOL (es tra DYE ole) vaginal ring is an insert that contains a female hormone. This medicine helps relieve symptoms of vaginal irritation and dryness that occurs in some women during menopause.
Dotti Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Transdermal patch - Biweekly
ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.
Climara Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Transdermal patch - Weekly
ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.
Imvexxy Maintenance Pack Drug Details (Brand)
Generic Name:
Therapeutic Class:
Availability:
Common Brands:
Form:
Vivelle-Dot Drug Details (Brand)
Generic Name:
Therapeutic Class:
Hormone Treatment
Availability:
Rx
Common Brands:
Form:
Transdermal patch - Biweekly
ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.
estradiol Uses (Generic)
What is estradiol used for?
Menopause (change of life or stopping the monthly menstrual cycle) is associated with falling estradiol levels. The medication estradiol is used for estrogen replacement to treat symptoms such as hot flashes and vaginal dryness in menopausal women. It is also used to prevent postmenopausal osteoporosis. Estradiol may also be used to relieve symptoms of certain types of breast cancer and prostate cancer.
How does estradiol work?
The follicle-stimulating hormone secreted by the pituitary gland in the brain causes estradiol levels to rise. Production of endogenous estrogens slows down significantly after menopause, as mentioned above. Synthetic estrogens like estradiol work by replacing estrogen in postmenopausal women. They relieve menopausal symptoms by binding to estrogen receptors.
What are estradiol doses?
Estradiol is available as 0.5 mg, 1 mg, and 2 mg tablets. The usual dose is 1 to 2 mg daily of estradiol to treat menopause symptoms. The lowest possible dose that controls symptoms is used for the shortest possible time. Your doctor will evaluate you at 3- to 6-month intervals to determine the need for continued treatment. The medication is recommended to be administered cyclically (for example, 3 weeks on, 1 week off).
For the treatment of invasive breast cancer, estradiol is given at a dose of 10 mg three times a day for at least 3 months.
Alora Uses (Brand)
Estradiol Uses
Estradiol is used for the treatment of menopausal symptoms such as hot flashes, night sweats, and vaginal dryness, itching, and burning. In women who only have vaginal symptoms, topical products such as estradiol vaginal cream or estradiol gel can be applied directly to the vagina and may be more beneficial.
Estradiol is also used to treat low estrogen levels due to castration, hypogonadism, and primary ovarian failure. This drug may be prescribed for palliative treatment of certain types of metastatic breast cancer and advanced androgen-dependent prostate cancer. Estradiol may be prescribed for the prevention of postmenopausal osteoporosis in women who cannot take non-estrogen medications.
There may be other uses of estradiol—your doctor or pharmacist can give you further drug information.
Estradiol Mechanism of Action
Estradiol is an estrogen hormone. It works by replacing the natural estrogen hormone in the body.
Estradiol Doses
Oral estradiol comes in the form of 0.5 mg, 1 mg, and 2 mg tablets. The recommended dosages are as follows:
- For menopausal symptoms: The usual initial dose of estradiol hormone therapy is 1 to 2 mg daily. This is adjusted to control postmenopausal symptoms. Your provider will start you at the lowest dose that controls your symptoms and reevaluate you at 3- to 6-month intervals to see if you need to continue on estradiol. They may ask you to take the medicine cyclically, i.e., 3 weeks on and 1 week off.
- For low estrogen due to castration, hypogonadism, or primary ovarian failure: The dose of estradiol is usually 1 to 2 mg daily. This is adjusted to control symptoms. The minimal effective dose is used for maintenance therapy.
- For palliative treatment of breast cancer with metastatic disease: The recommended dose of estradiol is 10 mg three times daily for three months or longer.
- For palliative treatment of advanced androgen-dependent prostate cancer: The recommended dose of estradiol is 1 to 2 mg three times daily.
- For prevention of postmenopausal osteoporosis: Estradiol is prescribed only to women who are at a significant risk of osteoporosis (bone loss) and in whom non-estrogen medications are not appropriate. The lowest effective dose of estradiol is used.
estradiol Directions (Generic)
How should I use estradiol?
Estradiol comes in the form of a tablet. You should take the tablet once a day with a glass of water. You can take this medication with or without food. Your doctor may ask you to take it every day or alternate taking it every day with a period of not taking the medication (for example, 3 weeks on, 1 week off).
Read your prescription label carefully and follow the directions. Do not take more or less of the medicine or take it for longer than advised by your doctor.
Your doctor may start you on a low dose of estradiol and adjust your dose based on your response.
Missed dose: If you forget to take estradiol, take your medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next dose at the regular time. Do not double up on the dose to make up for a missed dose.
Storage: Store estradiol in the container it came in, tightly closed and away from moisture, heat, and direct light. Keep all over-the-counter and prescription drugs out of reach of children.
Unused medicine: The best way to dispose of any unused or expired estradiol is through a medication take-back program. Learn more about proper medication disposal.
NOTE: This is a summary sheet, and the drug information contained here is for information purposes only. It does not constitute medical advice. If you have questions about estradiol or hormone replacement therapy, talk to your doctor or pharmacist for more information.
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Lyllana Directions (Brand)
How should I use LYLLANA?
This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Overdosage: If you think you have taken too much of LYLLANA contact a poison control center or emergency room at once. NOTE: LYLLANA is only for you. Do not share LYLLANA with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Yuvafem Directions (Brand)
Minivelle Directions (Brand)
How should I use Alora?
This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Overdosage: If you think you have taken too much of Alora contact a poison control center or emergency room at once. NOTE: Alora is only for you. Do not share Alora with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Vagifem Directions (Brand)
How should I use Yuvafem?
This medicine is for vaginal use only. Do not take by mouth. Follow the directions on the prescription label. Read package directions carefully before using. Wash hands before and after use. Use this medicine at bedtime. Do not use it more often than directed. Do not stop using except on your doctor''s advice.
Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.
Overdosage: If you think you have taken too much of Yuvafem contact a poison control center or emergency room at once. NOTE: Yuvafem is only for you. Do not share Yuvafem with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Evamist Directions (Brand)
How should I use Evamist?
This medicine is for external use only. Follow the directions on the prescription label. Your health care provider will show you how to apply this medicine. Apply this medicine at the same time each day to clean, dry, unbroken skin on the inside of the forearm between the elbow and the wrist. If you take a bath or shower or use a sauna, apply this medicine after the bath, shower, or sauna, and once the skin is dry. Avoid fire, flame or smoking until the spray has dried. Do not apply to the breast. Do not use your medicine more often than directed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of Evamist contact a poison control center or emergency room at once. NOTE: Evamist is only for you. Do not share Evamist with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Menostar Directions (Brand)
How should I use Menostar?
This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Overdosage: If you think you have taken too much of Menostar contact a poison control center or emergency room at once. NOTE: Menostar is only for you. Do not share Menostar with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Elestrin Directions (Brand)
How should I use Elestrin?
This medicine is for external use only. Follow the directions that come with your prescription. Spread the gel into a thin layer. It is not necessary to rub or massage the gel into the skin. Wash your hands with soap and water after applying the gel. Allow the gel to dry for up to 5 minutes before dressing. Avoid fire, flame or smoking until gel has dried. Do not apply to the breast, face or in or around the vagina. Do not use your medicine more often than directed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of Elestrin contact a poison control center or emergency room at once. NOTE: Elestrin is only for you. Do not share Elestrin with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Imvexxy Starter Pack Directions (Brand)
Alora Directions (Brand)
How To Use Estradiol
Oral estradiol comes in the form of a tablet to be taken by mouth 1-3 times daily. Taking this medication with food may help to reduce nausea. Try to take your medicine at around the same time(s) every day.
When estradiol is prescribed to menopausal women who have a uterus, another female sex hormone, progestin, is also prescribed to lower the risk of endometrial cancer. Women who do not have a uterus do not need progestin.
Estradiol alone or in combination with progestin is prescribed at the lowest effective dose for the shortest time possible. Your doctor will reevaluate you periodically at 3- or 6-month intervals to determine if estradiol treatment is still required. If you have a uterus, your doctor will order diagnostic tests, such as endometrial sampling, for early detection of endometrial cancer and to rule out cancer if you have unusual vaginal bleeding.
Read the prescription label carefully. Follow your doctor’s dosing instructions and take estradiol exactly as prescribed. Do not change the dose or dosing frequency without your doctor’s approval.
Missed dose: If you miss a dose of estradiol, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next dose according to your regular dosing schedule. Do not take a double dose or extra medicine to make up for a missed dose.
Storage: Store estradiol at room temperature (between 15-30° C or 59-86° F) away from moisture, heat, and direct light in its original container, tightly closed. Do not store medications in the bathroom, where they can be exposed to moisture and heat. Keep all medications safely out of reach of children and pets.
Unused medicine: Unused or expired estradiol should be disposed of in a way that children, other people, and pets cannot get to them. Do not throw estradiol in the trash or flush it down the toilet. The best way to dispose of expired or unneeded estradiol is through your local waste disposal company or a drug take-back program. Learn more about proper medication disposal.
NOTE: This medication guide is a summary and may not contain all possible drug information on estradiol. The information contained here may not be up-to-date. This sheet is for information purposes only. If you have questions about estradiol, talk to your healthcare professionals for medical advice.
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Divigel Directions (Brand)
This medicine is for external use only. Follow the directions that come with your prescription. Spread the gel into a thin layer. It is not necessary to rub or massage the gel into the skin. Wash your hands with soap and water after applying the gel. Allow the gel to dry for up to 5 minutes before dressing. Avoid fire, flame or smoking until gel has dried. Do not apply to the breast, face or in or around the vagina. Do not use your medicine more often than directed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
EstroGel Directions (Brand)
How should I use EstroGel?
This medicine is for external use only. Follow the directions that come with your prescription. Spread the gel into a thin layer. It is not necessary to rub or massage the gel into the skin. Wash your hands with soap and water after applying the gel. Allow the gel to dry for up to 5 minutes before dressing. Avoid fire, flame or smoking until gel has dried. Do not apply to the breast, face or in or around the vagina. Do not use your medicine more often than directed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of EstroGel contact a poison control center or emergency room at once. NOTE: EstroGel is only for you. Do not share EstroGel with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Estrace Directions (Brand)
How should I use Estrace?
Take this medicine by mouth. To reduce nausea, this medicine may be taken with food. Follow the directions on the prescription label. Take this medicine at the same time each day and in the order directed on the package. Do not take your medicine more often than directed.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Overdosage: If you think you have taken too much of Estrace contact a poison control center or emergency room at once. NOTE: Estrace is only for you. Do not share Estrace with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Estring Directions (Brand)
How should I use Estring?
This medicine may be inserted by you or your physician. Follow the directions that are included with your prescription. If you are unsure how to insert the ring, contact your doctor or health care professional. The vaginal ring should remain in place for 90 days. After 90 days you should replace your old ring and insert a new one. Do not stop using except on the advice of your doctor or health care professional.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Overdosage: If you think you have taken too much of Estring contact a poison control center or emergency room at once. NOTE: Estring is only for you. Do not share Estring with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Dotti Directions (Brand)
How should I use Estradiol?
This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Overdosage: If you think you have taken too much of Estradiol contact a poison control center or emergency room at once. NOTE: Estradiol is only for you. Do not share Estradiol with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Climara Directions (Brand)
How should I use Climara?
This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Overdosage: If you think you have taken too much of Climara contact a poison control center or emergency room at once. NOTE: Climara is only for you. Do not share Climara with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Imvexxy Maintenance Pack Directions (Brand)
Vivelle-Dot Directions (Brand)
How should I use DOTTI?
This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Overdosage: If you think you have taken too much of DOTTI contact a poison control center or emergency room at once. NOTE: DOTTI is only for you. Do not share DOTTI with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
estradiol Side Effects (Generic)
What are estradiol side effects?
The most common side effects of estradiol include:
- Headache
- Breast tenderness or breast pain
- Unusual vaginal bleeding or spotting in between menstrual periods
- Upset stomach, stomach cramps, nausea, vomiting, diarrhea, constipation
- Vaginal swelling, redness, itching, or burning
- Hair loss
- Unwanted hair growth
- Darkening of the skin in spots
- Weight gain
- Depression
- Nervousness
- Changes in sexual desire
- Difficulty wearing contact lenses
Tell your doctor if these side effects are severe or do not get better over time. Some side effects of estradiol are more serious. You should call your doctor immediately if you experience the following signs and symptoms:
- Bulging eyes
- Fever, chills, sore throat, cough, or other signs of infection
- Stomach pain, tenderness, or swelling
- Loss of appetite
- Weakness
- Joint pain
- Yellowing of the skin or eyes
- Difficulty controlling movements
- Hives, rash, blisters, itching
- Swelling of the face, tongue, throat, hands, or feet
- Difficulty breathing or swallowing
The above list may not include all the potential adverse effects of estradiol. Contact your doctor if you have severe adverse effects or your symptoms are worsening. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.
Estradiol Overdose: In case of a known or suspected overdose, get emergency medical help right away. Symptoms of an overdose of estradiol can include upset stomach, vomiting, and unusual vaginal bleeding.
NOTE: Estradiol is a prescription drug to be used only by you. Never share it with others or use someone else’s medication.
Source: FDA
Lyllana Side Effects (Brand)
What side effects may I notice from receiving LYLLANA?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast tissue changes or discharge
-changes in vision
-chest pain
-confusion, trouble speaking or understanding
-dark urine
-general ill feeling or flu-like symptoms
-light-colored stools
-nausea, vomiting
-pain, swelling, warmth in the leg
-right upper belly pain
-severe headaches
-shortness of breath
-sudden numbness or weakness of the face, arm or leg
-trouble walking, dizziness, loss of balance or coordination
-unusual vaginal bleeding
-yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-hair loss
-increased hunger or thirst
-increased urination
-symptoms of vaginal infection like itching, irritation or unusual discharge
-unusually weak or tired
This list may not describe all possible side effects for LYLLANA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAYuvafem Side Effects (Brand)
Minivelle Side Effects (Brand)
What side effects may I notice from receiving Alora?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast tissue changes or discharge
-changes in vision
-chest pain
-confusion, trouble speaking or understanding
-dark urine
-general ill feeling or flu-like symptoms
-light-colored stools
-nausea, vomiting
-pain, swelling, warmth in the leg
-right upper belly pain
-severe headaches
-shortness of breath
-sudden numbness or weakness of the face, arm or leg
-trouble walking, dizziness, loss of balance or coordination
-unusual vaginal bleeding
-yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-hair loss
-increased hunger or thirst
-increased urination
-symptoms of vaginal infection like itching, irritation or unusual discharge
-unusually weak or tired
This list may not describe all possible side effects for Alora. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAVagifem Side Effects (Brand)
What side effects may I notice from receiving Yuvafem?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast lumps, tissue changes, or discharge
-increased blood pressure
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
-signs and symptoms of a blood clot such as breathing problems; changes in vision or speech; chest pain; severe, sudden headache; pain, swelling, warmth in the leg; trouble speaking; sudden numbness or weakness of the face, arm or leg
-swelling in your ankles, legs, or feet
-vaginal discharge, itching, or odor
-unusual vaginal bleeding
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
-breast tenderness or pain
-headache
-nausea
This list may not describe all possible side effects for Yuvafem. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAEvamist Side Effects (Brand)
What side effects may I notice from receiving Evamist?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast tissue changes or discharge
-changes in vision
-chest pain
-confusion, trouble speaking or understanding
-dark urine
-general ill feeling or flu-like symptoms
-light-colored stools
-nausea, vomiting
-pain, swelling, warmth in the leg
-right upper belly pain
-severe headaches
-shortness of breath
-sudden numbness or weakness of the face, arm or leg
-trouble walking, dizziness, loss of balance or coordination
-unusual vaginal bleeding
-yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-hair loss
-increased hunger or thirst
-increased urination
-irritation or mild redness at the application site
-symptoms of vaginal infection like itching, irritation or unusual discharge
This list may not describe all possible side effects for Evamist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAMenostar Side Effects (Brand)
What side effects may I notice from receiving Menostar?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast tissue changes or discharge
-changes in vision
-chest pain
-confusion, trouble speaking or understanding
-dark urine
-general ill feeling or flu-like symptoms
-light-colored stools
-nausea, vomiting
-pain, swelling, warmth in the leg
-right upper belly pain
-severe headaches
-shortness of breath
-sudden numbness or weakness of the face, arm or leg
-trouble walking, dizziness, loss of balance or coordination
-unusual vaginal bleeding
-yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-hair loss
-increased hunger or thirst
-increased urination
-symptoms of vaginal infection like itching, irritation or unusual discharge
-unusually weak or tired
This list may not describe all possible side effects for Menostar. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAElestrin Side Effects (Brand)
What side effects may I notice from receiving Elestrin?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast lumps, tissue changes, or discharge
-high blood pressure
-migraines or severe, sudden headaches
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
-signs and symptoms of a blood clot such as breathing problems; changes in vision or speech; chest pain; severe, sudden headache; pain, swelling, warmth in the leg; trouble speaking; sudden numbness or weakness of the face, arm or leg
-swelling in your ankles, legs, or feet
-unusual vaginal bleeding
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
-breast tenderness or pain
-hair loss
-mild headache
-nausea, vomiting
-upset stomach
This list may not describe all possible side effects for Elestrin. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAImvexxy Starter Pack Side Effects (Brand)
Alora Side Effects (Brand)
Estradiol Side Effects
Common side effects of estradiol are listed below. Tell your doctor if these side effects are severe or persistent after a few days:
- Headache
- Breast pain
- Abnormal or unusual vaginal bleeding or spotting
- Fluid retention and bloating
- Nausea
- Stomach cramps
- Vomiting
- Mood changes, anxiety, irritability, depression, sleep problems
- Weight gain
- Darkening of the facial skin
- Thinning scalp hair
Estradiol can also cause more serious side effects. Contact your doctor for medical advice about side effects or seek emergency medical attention if you develop:
- Signs and symptoms of allergic reactions, such as skin rash, hives, itching, blisters, peeling
- Swelling of the face, eyes, lips, tongue, or throat
- Difficulty breathing or swallowing
- Wheezing
- Hoarseness
- Signs and symptoms of blood clots such as chest pain, shortness of breath, or pain, swelling, or warmth in one or both legs
- Changes in your breasts, such as pain, lumps, redness, or nipple discharge
- Signs and symptoms of gallbladder problems, such as stomach pain, nausea, vomiting, fever
- Signs and symptoms of liver injury, such as nausea, vomiting, right upper stomach pain, loss of appetite, light-colored stools, dark urine, fatigue, yellowing of the skin or eyes
- Signs and symptoms of a vaginal infection or vaginal irritation (vaginal itching, burning, discharge, odor, redness, or swelling)
- Pelvic pain or unusual vaginal bleeding after menopause
- Breakthrough bleeding between menstrual periods
The above list may not include all the potential adverse effects of estradiol. Contact your healthcare professional if the side effects are unusual or severe or if they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.
Estradiol Overdose: In case of an overdose, call your doctor immediately. You can also call your local poison control center or the national poison control center at 1-800-222-1222. If a person cannot be awakened, has trouble breathing, has collapsed, or has had a seizure, call 911. Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, fatigue, breast pain, and unusual vaginal bleeding.
Source: FDA
Divigel Side Effects (Brand)
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast lumps, tissue changes, or discharge
-high blood pressure
-migraines or severe, sudden headaches
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
-signs and symptoms of a blood clot such as breathing problems; changes in vision or speech; chest pain; severe, sudden headache; pain, swelling, warmth in the leg; trouble speaking; sudden numbness or weakness of the face, arm or leg
-swelling in your ankles, legs, or feet
-unusual vaginal bleeding
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
-breast tenderness or pain
-hair loss
-mild headache
-nausea, vomiting
-upset stomach
EstroGel Side Effects (Brand)
What side effects may I notice from receiving EstroGel?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast lumps, tissue changes, or discharge
-high blood pressure
-migraines or severe, sudden headaches
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
-signs and symptoms of a blood clot such as breathing problems; changes in vision or speech; chest pain; severe, sudden headache; pain, swelling, warmth in the leg; trouble speaking; sudden numbness or weakness of the face, arm or leg
-swelling in your ankles, legs, or feet
-unusual vaginal bleeding
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
-breast tenderness or pain
-hair loss
-mild headache
-nausea, vomiting
-upset stomach
This list may not describe all possible side effects for EstroGel. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAEstrace Side Effects (Brand)
What side effects may I notice from receiving Estrace?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast tissue changes or discharge
-changes in vision
-chest pain
-confusion, trouble speaking or understanding
-dark urine
-general ill feeling or flu-like symptoms
-light-colored stools
-nausea, vomiting
-pain, swelling, warmth in the leg
-right upper belly pain
-severe headaches
-shortness of breath
-sudden numbness or weakness of the face, arm or leg
-trouble walking, dizziness, loss of balance or coordination
-unusual vaginal bleeding
-yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-hair loss
-increased hunger or thirst
-increased urination
-symptoms of vaginal infection like itching, irritation or unusual discharge
-unusually weak or tired
This list may not describe all possible side effects for Estrace. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAEstring Side Effects (Brand)
What side effects may I notice from receiving Estring?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast tissue changes or discharge
-signs and symptoms of a blood clot such as breathing problems; changes in vision; chest pain; severe, sudden headache; pain, swelling, warmth in the leg; trouble speaking; sudden numbness or weakness of the face, arm or leg
-signs and symptoms of infection like fever or chills; vomiting; diarrhea; muscle pain; dizziness; or a red, sunburn-like rash on face and body
-signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
-symptoms of bowel blockage like constipation, abdominal swelling, abdominal pain, inability to pass gas or have a bowel movement
-symptoms of vaginal infection like itching, irritation or unusual discharge
-unusual or increased vaginal bleeding
-vaginal pain or soreness, redness, swelling
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-breast tenderness
-fluid retention
-hair loss
-headache
-nausea
-upset stomach
-vaginal spotting
This list may not describe all possible side effects for Estring. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDADotti Side Effects (Brand)
What side effects may I notice from receiving Estradiol?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast tissue changes or discharge
-changes in vision
-chest pain
-confusion, trouble speaking or understanding
-dark urine
-general ill feeling or flu-like symptoms
-light-colored stools
-nausea, vomiting
-pain, swelling, warmth in the leg
-right upper belly pain
-severe headaches
-shortness of breath
-sudden numbness or weakness of the face, arm or leg
-trouble walking, dizziness, loss of balance or coordination
-unusual vaginal bleeding
-yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-hair loss
-increased hunger or thirst
-increased urination
-symptoms of vaginal infection like itching, irritation or unusual discharge
-unusually weak or tired
This list may not describe all possible side effects for Estradiol. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAClimara Side Effects (Brand)
What side effects may I notice from receiving Climara?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast tissue changes or discharge
-changes in vision
-chest pain
-confusion, trouble speaking or understanding
-dark urine
-general ill feeling or flu-like symptoms
-light-colored stools
-nausea, vomiting
-pain, swelling, warmth in the leg
-right upper belly pain
-severe headaches
-shortness of breath
-sudden numbness or weakness of the face, arm or leg
-trouble walking, dizziness, loss of balance or coordination
-unusual vaginal bleeding
-yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-hair loss
-increased hunger or thirst
-increased urination
-symptoms of vaginal infection like itching, irritation or unusual discharge
-unusually weak or tired
This list may not describe all possible side effects for Climara. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAImvexxy Maintenance Pack Side Effects (Brand)
Vivelle-Dot Side Effects (Brand)
What side effects may I notice from receiving DOTTI?
Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-breast tissue changes or discharge
-changes in vision
-chest pain
-confusion, trouble speaking or understanding
-dark urine
-general ill feeling or flu-like symptoms
-light-colored stools
-nausea, vomiting
-pain, swelling, warmth in the leg
-right upper belly pain
-severe headaches
-shortness of breath
-sudden numbness or weakness of the face, arm or leg
-trouble walking, dizziness, loss of balance or coordination
-unusual vaginal bleeding
-yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-hair loss
-increased hunger or thirst
-increased urination
-symptoms of vaginal infection like itching, irritation or unusual discharge
-unusually weak or tired
This list may not describe all possible side effects for DOTTI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Source: FDAestradiol Warnings (Generic)
What are the risks of using estradiol?
Estradiol can cause serious health problems, especially in certain high-risk patients. Please talk to your doctor or pharmacist about other treatment options if these are a concern for you.
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What should I tell my doctor before using estradiol?
Tell your doctor if you are allergic to estradiol, other estrogen products, or other medications. Your local pharmacy can provide you with a list of ingredients in estradiol tablets. Specifically, tell your doctor if you are allergic to tartrazine (a food coloring) or aspirin if you are taking the brand name medication Estrace (which contains estradiol as the active ingredient).
Give your doctor and pharmacist a complete list of all your current medicines, including prescription and nonprescription medications, vitamins, and nutritional supplements, especially if you take St. John’s Wort.
Give your doctor a complete health history. Specifically, tell your healthcare provider if you have ever had liver problems (yellowing skin or eyes) during estrogen treatment or pregnancy. Also, tell your doctor if you have endometriosis, uterine fibroid tumors, diabetes, asthma, seizures, migraine headaches, porphyria, abnormal calcium levels, or diseases of the thyroid, kidney, liver, gallbladder, or pancreas.
Talk to your doctor about drinking grapefruit juice or eating grapefruit while taking estradiol.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Estradiol can slow breast milk production.
If you are over 65, talk to your doctor about the risks versus benefits of taking estradiol.
If you are taking estradiol to prevent osteoporosis, talk to your doctor about other ways to prevent this condition, such as exercise and taking calcium and vitamin D supplements.
What precautions should I take while using estradiol?
Keep all your appointments at your doctor’s office. Your doctor may adjust your dose of estradiol based on your response. Tell your doctor immediately if you become pregnant while taking estradiol.
What are estradiol interactions?
Using estradiol with other medications can affect how the drug works or increase the risk of severe side effects. Your physician may choose a different medication, change the dose or frequency of your medicines, and/or monitor you carefully for side effects if there are known drug interactions. There can be drug interactions between estradiol and other medications, such as:
- Heart medications such as amiodarone (Cordarone, Pacerone), diltiazem (Cardizem, Dilacor, Tiazac, others), and verapamil (Calan, Covera, Isoptin, Verelan)
- Cholesterol-lowering drugs like lovastatin (Altocor, Mevacor)
- Some antifungals like itraconazole (Sporanox), ketoconazole (Nizoral), and griseofulvin (Fulvicin, Grifulvin, Gris-PEG);
- Certain antiepileptic drugs like carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek)
- Aprepitant (Emend)
- Cimetidine (Tagamet)
- Certain antibiotics like clarithromycin (Biaxin) and erythromycin (E.E.S, Erythrocin)
- Cyclosporine (Neoral, Sandimmune)
- Dexamethasone (Decadron, Dexpak)
- Certain antidepressants like fluoxetine (Prozac, Sarafem), sertraline (Zoloft), and fluvoxamine (Luvox)
- Some HIV medications
- Medications for thyroid disease
- Nefazodone
- Rifampin (Rifadin, Rimactane, in Rifamate)
- Rifabutin (Mycobutin)
- Troleandomycin (TAO)
- Zafirlukast (Accolate)
Not all possible interactions are included in this list. Give your healthcare provider a complete list of your medications, including prescription drugs, over-the-counter medicines, dietary supplements, vitamins, and herbal remedies. Also, tell your healthcare provider if you smoke, drink alcohol, or use illegal drugs because some of these substances can cause serious health complications when used with prescription drugs
Lyllana Warnings (Brand)
What may interact with LYLLANA?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-carbamazepine
-certain antibiotics used to treat infections
-certain barbiturates used for inducing sleep or treating seizures
-grapefruit juice
-medicines for fungus infections like itraconazole and ketoconazole
-raloxifene or tamoxifen
-rifabutin, rifampin, or rifapentine
-ritonavir
-St. John''s Wort
What should I tell my health care provider before I take LYLLANA?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using LYLLANA?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
Contact with water while you are swimming, using a sauna, bathing, or showering may cause the patch to fall off. If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area and continue to follow your usual dose schedule.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.
Yuvafem Warnings (Brand)
Minivelle Warnings (Brand)
What may interact with Alora?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-carbamazepine
-certain antibiotics used to treat infections
-certain barbiturates used for inducing sleep or treating seizures
-grapefruit juice
-medicines for fungus infections like itraconazole and ketoconazole
-raloxifene or tamoxifen
-rifabutin, rifampin, or rifapentine
-ritonavir
-St. John''s Wort
What should I tell my health care provider before I take Alora?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using Alora?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
Contact with water while you are swimming, using a sauna, bathing, or showering may cause the patch to fall off. If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area and continue to follow your usual dose schedule.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.
Vagifem Warnings (Brand)
What may interact with Yuvafem?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentene
-raloxifene or tamoxifen
-warfarin
What should I tell my health care provider before I take Yuvafem?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using Yuvafem?
Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.
If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.
If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
Evamist Warnings (Brand)
What may interact with Evamist?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentine
-antiviral medicines for HIV or AIDS
-certain antibiotics like erythromycin and clarithromycin
-carbamazepine
-grapefruit juice
-medicines for fungal infections like ketoconazole and itraconazole
-phenobarbital
-raloxifene
-tamoxifen
-St. John''s Wort
What should I tell my health care provider before I take Evamist?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using Evamist?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
This medicine can transfer from your body to others. If a person or pet comes in contact with the area where this medicine was applied to your skin, they may have a serious risk of side effects. If you cannot avoid skin-to-skin contact with another person, make sure the site where this medicine was applied is covered with clothing. If accidental contact happens, the skin of the person or pet should be washed right away with soap and water.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
Menostar Warnings (Brand)
What may interact with Menostar?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-carbamazepine
-certain antibiotics used to treat infections
-certain barbiturates used for inducing sleep or treating seizures
-grapefruit juice
-medicines for fungus infections like itraconazole and ketoconazole
-raloxifene or tamoxifen
-rifabutin, rifampin, or rifapentine
-ritonavir
-St. John''s Wort
What should I tell my health care provider before I take Menostar?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using Menostar?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
Contact with water while you are swimming, using a sauna, bathing, or showering may cause the patch to fall off. If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area and continue to follow your usual dose schedule.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.
Elestrin Warnings (Brand)
What may interact with Elestrin?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentene
-raloxifene or tamoxifen
-warfarin
What should I tell my health care provider before I take Elestrin?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-thyroid disease
-an unusual or allergic reaction to estrogens, other hormones, soy, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using Elestrin?
Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.
Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.
If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
Imvexxy Starter Pack Warnings (Brand)
Alora Warnings (Brand)
Estradiol Risks, Warnings, and Complications
Estradiol can cause or worsen health problems in some people. Talk to your doctor about other treatment options if you are at an increased risk of complications from this medicine. Some of the risks of estradiol use include:
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Precautions Before Starting Estradiol
Tell your doctor if you have had an allergic reaction to estradiol, any of the active or inactive ingredients in estradiol formulations, other estrogen preparations, or any other medications. Your pharmacy can give you a list of ingredients.
Give your doctor or pharmacist a complete list of your medications, including prescription drugs, nonprescription drugs, vitamins, supplements, and herbal products such as St. John’s Wort. This can help avoid possible interactions between estradiol and your other medicines.
Give your doctor a complete medical history. Estradiol may not be right for people with certain medical conditions, such as personal or family medical history or breast, endometrial, or ovarian cancer, asthma, migraines, epilepsy or other seizure disorder, a bleeding disorder, uterine fibroid tumors, endometriosis, jaundice during pregnancy while using estrogen, hypoparathyroidism (low parathyroid hormone levels), high or low calcium levels, a genetic enzyme disorder called porphyria, a hereditary blood disorder such as hereditary angioedema, liver disease, gallbladder disease, kidney disease, thyroid disorder, or pancreas problems.
Talk to your doctor about eating grapefruit or drinking grapefruit juice while on this medicine.
Tell your doctor if you are pregnant, could be pregnant, are planning a pregnancy, or are breast feeding. Estrogens can slow breast milk production in lactating women.
Precautions During Use of Estradiol
Keep all your medical and lab appointments while on estradiol. Tell your healthcare professional if your menopausal symptoms do not improve or get worse on this medicine. Do not change the dose or dosing frequency without talking to your doctor first.
Tell all your healthcare providers you are on estradiol before a minor or major surgery, including dental treatments.
Tell your healthcare professional if you become pregnant while on estradiol.
Estradiol Drug Interactions
Taking estradiol with certain other drugs can affect how the medicines work. Possible interactions between estradiol and other medications can increase the risk of serious adverse events. Your doctor may change the dose of your medications, switch you to another medication, or monitor you carefully for side effects if there are known interactions between estradiol and your other medicines. Estradiol can have drug interactions with the following medications:
Anti-seizure medications such as phenobarbital and carbamazepine
Anti-tubercular drugs like rifampin
Antibiotics such as erythromycin and clarithromycin
Antifungal agents such as ketoconazole and itraconazole
HIV medications such as ritonavir
Herbal remedies such as St. John’s Wort (Hypericum perforatum)
The above list may not include all the possible drug interactions of estradiol. Give your healthcare professional a complete list of all the medications you are taking, including prescription drugs, non-prescription medicines, dietary supplements, and herbal remedies. Also, tell your healthcare provider if you smoke, drink alcohol, or use recreational drugs because some of these substances can cause serious health complications when used with prescription and over-the-counter medicines.
Divigel Warnings (Brand)
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentene
-raloxifene or tamoxifen
-warfarin
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-thyroid disease
-an unusual or allergic reaction to estrogens, other hormones, soy, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.
Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.
If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
EstroGel Warnings (Brand)
What may interact with EstroGel?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentene
-raloxifene or tamoxifen
-warfarin
What should I tell my health care provider before I take EstroGel?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-thyroid disease
-an unusual or allergic reaction to estrogens, other hormones, soy, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using EstroGel?
Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.
Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.
If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
Estrace Warnings (Brand)
What may interact with Estrace?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-carbamazepine
-certain antibiotics used to treat infections
-certain barbiturates or benzodiazepines used for inducing sleep or treating seizures
-grapefruit juice
-medicines for fungus infections like itraconazole and ketoconazole
-raloxifene or tamoxifen
-rifabutin, rifampin, or rifapentine
-ritonavir
-St. John''s Wort
-warfarin
What should I tell my health care provider before I take Estrace?
They need to know if you have or ever had any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using Estrace?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date.
Estring Warnings (Brand)
What may interact with Estring?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone, vorozole
This medicine may also interact with the following medications:
-carbamazepine
-certain antibiotics used to treat infections
-certain barbiturates used for inducing sleep or treating seizures
-grapefruit juice
-medicines for fungus infections like itraconazole and ketoconazole
-raloxifene or tamoxifen
-rifabutin, rifampin, or rifapentine
-ritonavir
-St. John''s Wort
What should I tell my health care provider before I take Estring?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using Estring?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
You may bathe or participate in other activities while using this medicine. You do not need to remove the vaginal ring during sexual or other activities unless you are more comfortable doing so. Within the 90-day dosage period, you may remove the vaginal ring, rinse it with clean lukewarm (not hot or boiling) water, and re-insert the ring as needed.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Throw away any unused medicine after the expiration date.
Dotti Warnings (Brand)
What may interact with Estradiol?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-carbamazepine
-certain antibiotics used to treat infections
-certain barbiturates used for inducing sleep or treating seizures
-grapefruit juice
-medicines for fungus infections like itraconazole and ketoconazole
-raloxifene or tamoxifen
-rifabutin, rifampin, or rifapentine
-ritonavir
-St. John''s Wort
What should I tell my health care provider before I take Estradiol?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using Estradiol?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
Contact with water while you are swimming, using a sauna, bathing, or showering may cause the patch to fall off. If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area and continue to follow your usual dose schedule.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.
Climara Warnings (Brand)
What may interact with Climara?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-carbamazepine
-certain antibiotics used to treat infections
-certain barbiturates used for inducing sleep or treating seizures
-grapefruit juice
-medicines for fungus infections like itraconazole and ketoconazole
-raloxifene or tamoxifen
-rifabutin, rifampin, or rifapentine
-ritonavir
-St. John''s Wort
What should I tell my health care provider before I take Climara?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using Climara?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
Contact with water while you are swimming, using a sauna, bathing, or showering may cause the patch to fall off. If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area and continue to follow your usual dose schedule.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.
Imvexxy Maintenance Pack Warnings (Brand)
Vivelle-Dot Warnings (Brand)
What may interact with DOTTI?
Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
This medicine may also interact with the following medications:
-carbamazepine
-certain antibiotics used to treat infections
-certain barbiturates used for inducing sleep or treating seizures
-grapefruit juice
-medicines for fungus infections like itraconazole and ketoconazole
-raloxifene or tamoxifen
-rifabutin, rifampin, or rifapentine
-ritonavir
-St. John''s Wort
What should I tell my health care provider before I take DOTTI?
They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
What should I watch for while using DOTTI?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
Contact with water while you are swimming, using a sauna, bathing, or showering may cause the patch to fall off. If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area and continue to follow your usual dose schedule.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.
estradiol Pros & Cons (Generic)
What are the pros and cons of estradiol?
- Estradiol is available as an oral tablet, which is easier to use than a vaginal cream, topical gel, or ring.
- It is available as a low-cost generic drug.
- The tablets come in various strengths, so it’s easy to customize the dose.
- Estradiol helps to prevent bone loss and weak bones after menopause.
- It can be challenging to keep track of cyclic estradiol administration (for example, 3 weeks off, 1 week on).
- Estradiol can increase your risk of certain types of cancers and cardiovascular disease.
- It can worsen certain health conditions like diabetes and asthma.
- There are other, safer treatments available to prevent osteoporosis (bone loss).
Alora Pros & Cons (Brand)
Estradiol Pros and Cons
- Estradiol can help manage symptoms of menopause (symptoms that occur around the time you stop getting your menstrual cycle).
- This medication can lower the risk of osteoporosis (bone loss) after menopause.
- It comes as an oral tablet as well as topical products for application to the vagina.
- It is available in a lower-cost generic form.
- It can be difficult to remember to take estradiol cyclically (3 weeks on, 1 week off).
- Taking estrogen replacement therapy can increase your risk of hormone-related cancer, blood clots, heart attack, and stroke.
estradiol Pharmacist Tips (Generic)
Estradiol tips from pharmacists
Taking estradiol can increase your risk of many serious health conditions. Talk to your reproductive health care professional about the benefits versus risks of this medication.
Talk to your doctor about other treatment options for osteoporosis. Estradiol is not the first-choice medication to prevent bone loss after menopause.
Check your breasts every month for any unusual lumps or swelling while taking estradiol.
Estradiol can increase your risk of blood clots. Tell your doctors you are taking this medication if scheduled for surgery.
Alora Pharmacist Tips (Brand)
Estradiol Tips from Pharmacists
Oral estradiol is associated with a higher risk of serious health conditions, such as heart attack and stroke. If you only have symptoms affecting the vagina locally, such as vaginal dryness, talk to your doctor about using estradiol vaginal cream or estradiol gel instead of tablets.
Estradiol can increase the risk of breast carcinoma. Follow your doctor’s recommendations for doing a monthly self-breast exam and getting screening tests done to detect breast tumors early.
If you still have a uterus, keep your appointments for endometrial sampling for early detection of uterine cancer.]
Tell your healthcare providers you are on estradiol before any surgery. You may need to stop taking this medicine for 4-6 weeks because it can increase the risk of blood clots.
estradiol Rx Savings Tips (Generic)
Estradiol Rx savings tips
Estradiol is a generic medication available at significantly lower prices than the brand name. Estrace and generic estradiol contain the same active ingredient and are equally effective and safe. Like with most medications, estradiol generic offers better value. However, a BuzzRx Estrace coupon can result in big savings on the brand-name drug. With a BuzzRx discount card, savings card, or discount coupons, the medication could cost you a fraction of retail prices. A tube of Estrace cream may be under $351.34 at Walmart, Walgreens, Kroger, CVS Pharmacy, and other participating pharmacies. For the biggest discounts on estradiol or Estrace, make sure you provide your coupon when you drop off your prescription.
Lowest Price for Estradiol | |
| Brand $351.34 | Generic $35.81 |
VIEW DISCOUNTS Pricing based on most commonly-filled versions. Select the strength and quantity of your medication for the most accurate pricing. | |
Alora Rx Savings Tips (Brand)
Estradiol Rx Savings Tips
Estradiol is a generic medication. It is available at significantly lower prices than the brand name Estrace (this product is no longer on the market). Brand name Estrace and generic estradiol contain the same medicine and are equally effective and safe. As with most medications, the generic form offers better value. A BuzzRx estradiol coupon can result in big savings on the generic form of the drug. With a BuzzRx discount card, savings card, or discount coupons, the medication could cost you a fraction of retail prices. Estradiol may be under $50.00 for one tube of cream of the 42.5 g of 0.01% dose at Walmart, Walgreens, Rite Aid, CVS Pharmacy, and other participating pharmacies with a BuzzRx discount card or free coupon. For the biggest discounts on estradiol, give the checkout clerk your BuzzRx estradiol discount coupon when you drop off your prescriptions at the pharmacy counter.
Lowest Price for Estradiol | |
| Brand $124.40 | Generic $49.99 |
VIEW DISCOUNTS Pricing based on most commonly-filled versions. Select the strength and quantity of your medication for the most accurate pricing. | |
estradiol Common Questions (Generic)
Common Questions about estradiol
Is weight gain a side effect of estradiol?Weight gain can be a side effect of estradiol. However, it is worth noting that women tend to gain weight around their midsection after menopause, so the extra weight may not be from the medication. If you are concerned about weight gain, your doctor can provide medical advice about alternative treatments. |
Can estradiol cause hair loss?Estradiol can cause both hair loss and unwanted hair growth. Tell your healthcare professional if these adverse effects are severe or do not go away with time. |
How long can estradiol be taken?Taking estradiol is associated with several serious health risks. This medication is generally prescribed at the lowest dose that relieves menopausal symptoms, and it is used for the shortest possible time. Your doctor will review the need to continue treatment every 3-6 months. You should work with your doctor to decide how long you should stay on this medication. |
Can you quit estradiol cold turkey?Yes, you can stop taking estradiol cold turkey (suddenly) and do just fine. However, you may have a return of your menopause symptoms when you stop taking hormone replacement therapy. |
Can you take HRT on alternate days?It is not recommended that you take hormone replacement therapy on alternate days, as this can cause fluctuations in your blood hormone levels. |
What is the price of estradiol without insurance?Without insurance, estradiol can be as high as $87.65, but with a free BuzzRx prescription discount coupon, you could pay as low as $35.81 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price and enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions of estradiol like Estrace, Yuvafem, Vivelle-Dot, EstroGel, and Alora. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not. |
What is the price of estradiol with insurance?Ask your pharmacist or insurance provider for your copay price on estradiol—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins. You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for estradiol. When using the BuzzRx lookup tool to find the price of your medication, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not. |
Alora Common Questions (Brand)
Common Questions about Estradiol
Is estradiol the same as estrogen?Yes, estradiol is the most potent estrogen. It is the man-made version of the hormone that is naturally found in the body. |
How long can I take estradiol for postmenopausal symptoms?Estradiol increases your risk of serious health complications such as blood clots, heart attack, stroke, and certain cancers. You should take this medication at the lowest effective dose for the shortest possible time. Your healthcare provider will review you every 3-6 months and decide if you should continue on this medication. |
Does estradiol cause weight gain?Some people experience an increase in weight on estradiol, while others notice weight loss. Estradiol may make you feel more full and thereby control your appetite, leading to weight loss. On the other hand, estradiol can cause fluid retention and may cause some increase in weight. If weight changes are a concern, talk to your healthcare provider. |
Do I need estradiol oral tablets or vaginal cream?Whether you need estradiol oral tablets or estradiol vaginal cream/estradiol gel depends on your symptoms. If you have symptoms such as vaginal dryness or vaginal itching, your provider may recommend a topical product such as an estradiol vaginal cream or gel. On the other hand, if your symptoms are hot flashes and night sweats, you may need to take the tablet. |
What to avoid when taking estradiol?Your provider may ask you to avoid eating grapefruit and drinking grapefruit juice while on estradiol as this can lead to increased plasma concentrations of the medicine and increased side effects. |
What is the price of estradiol without insurance?Without insurance, estradiol can be as high as $226.30, but with a free BuzzRx prescription discount coupon, you could pay as low as $49.99 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescription drugs—whether you have insurance or not. |
What is the price of estradiol with insurance?Ask your pharmacist or insurance provider for your copay price on estradiol—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins. You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for estradiol. When using the BuzzRx lookup tool to find the price of your medicine, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not. |
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