-aprepitant
-bosentan
-certain antibiotics like clarithromycin, erythromycin, telithromycin, or troleandomycin
-certain antivirals for HIV or hepatitis
-certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, or posaconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-ciprofloxacin
-conivaptan
-cyclosporine
-diltiazem
-dronedarone
-fluvoxamine
-grapefruit juice
-nefazodone
-rifampin
-St. John''s Wort
-verapamil

They need to know if you have any of these conditions:

-bleeding in the brain
-bulging or weak blood vessel wall
-low platelets
-stroke
-an unusual or allergic reaction to avapritinib, other medicines, foods, dyes or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. It may be some time before you see the benefit from this medicine.
Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduced the risk of dizzy or fainting spells.
Do not become pregnant while taking this medicine or for 6 weeks after stopping it. Women should inform their health care provider if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 6 weeks after stopping it. There is potential for serious side effects to an unborn child. Talk to your health care provider for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after stopping it.
This medicine may make it more difficult to get pregnant or father a child. Talk to your health care provider if you are concerned about your fertility.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, empty the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.