-alcohol
-antihistamines for allergy, cough, or cold
-aprepitant
-boceprevir
-certain antibiotics like ciprofloxacin, clarithromycin, erythromycin, telithromycin
-certain antivirals for HIV or AIDS
-certain medicines for anxiety or sleep
-certain medicines for depression like amitriptyline, fluoxetine, nefazodone, sertraline
-certain medicines for fungal infections like ketoconazole, posaconazole, fluconazole, itraconazole
-certain medicines for seizures like carbamazepine, phenobarbital, primidone, phenytoin
-conivaptan
-digoxin
-diltiazem
-general anesthetics like halothane, isoflurane, methoxyflurane, propofol
-grapefruit juice
-imatinib
-medicines that relax muscles for surgery
-narcotic medicines for pain
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
-rifampin
-verapamil

They need to know if you have any of these conditions:

-depression
-drink alcohol
-drug abuse or addiction
-feel sleepy or have fallen asleep suddenly during the day
-history of a sudden onset of muscle weakness (cataplexy)
-liver disease
-lung or breathing disease, like asthma or emphysema
-sleep apnea
-suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
-an unusual or allergic reaction to suvorexant, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care professional for regular checks on your progress. Tell your health care professional if your symptoms do not start to get better or if they get worse. Avoid caffeine-containing drinks in the evening hours.

After taking this medicine, you may get up out of bed and do an activity that you do not know you are doing. The next morning, you may have no memory of this. Activities include driving a car ("sleep-driving"), making and eating food, talking on the phone, sexual activity, and sleep-walking. Serious injuries have occurred. Call your doctor right away if you find out you have done any of these activities. Do not take this medicine if you have used alcohol that evening. Do not take it if you have taken another medicine for sleep.

Do not take this medicine unless you are able to stay in bed for a full night (7 to 8 hours) and do not drive or perform other activities requiring full alertness within 8 hours of a dose. Do not drive, use machinery, or do anything that needs mental alertness the day after you take the 20 mg dose of this medicine. The use of lower doses (10 mg) may also cause driving impairment the next day. You may have a decrease in mental alertness the day after use, even if you feel that you are fully awake. Tell your doctor if you will need to perform activities requiring full alertness, such as driving, the next day. Do not stand or sit up quickly after taking this medicine, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.



If you or your family notice any changes in your behavior, such as new or worsening depression, thoughts of harming yourself, anxiety, other unusual or disturbing thoughts, or memory loss, call your health care professional right away.




After you stop taking this medicine, you may have trouble falling asleep. This is called rebound insomnia. This problem usually goes away on its own after 1 or 2 nights.

Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.