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Tranexamic acid is a skin-brightening agent that is generally safe for all skin types to improve uneven skin tone. Please continue reading to find out how tranexamic acid can improve the skin's overall appearance by reducing the appearance of dark spots and acne scars.

How does tranexamic acid correct skin discoloration?

Oral tranexamic acid (commonly called TXA) is used to control heavy menstrual bleeding by delaying the breakdown of blood clots. For major surgeries, trauma, postpartum bleeding, or other emergent medical situations, TXA can be administered intravenously (into a vein) or intra-articularly (into a joint space). 

Tranexamic acid is a synthetic derivative of lysine, a naturally occurring amino acid. Lysine plays a vital role in collagen production. Therefore, structurally similar to lysine, tranexamic acid is a beneficial addition to our routine skincare regimen. 

Tranexamic acid interferes with melanin production in the skin by putting a halt to inflammation signals and blocking UV effects. By reducing inflammation in the skin that normally triggers melanin production and blocking skin cells from sending signals that increase melanin after exposure to sunlight, melanin levels decrease. The use of topical tranexamic acid helps to diminish the appearance of uneven skin tone and prevent the formation of new discoloration.

In the late 1970s, it was discovered that a topical tranexamic acid derivative has benefits for the skin and could be a promising treatment for various dermatologic conditions. 

What can tranexamic acid do for my skin?

If you have sun-damaged skin, introducing tranexamic acid into your skincare routine may help to make your skin brighter. Tranexamic acid can fade dark spots and sun spots and make areas of hyperpigmentation appear lighter.

Topical tranexamic acid can be used for treating melasma, chronic urticaria, post-inflammatory hyperpigmentation, and rosacea. It can also be used for post-acne erythema treatment (redness and acne scars). Read about Benzoyl Peroxide for Acne: Side Effects & Benefits.

Studies have shown that application of 3% tranexamic acid once daily for 2 weeks leads to an improvement in rosacea symptoms. Rosacea is a skin condition associated with a profoundly diminished skin barrier. Researchers believe the positive effects of tranexamic acid are linked to the strengthening of the outermost layer of skin and improvement in skin barrier function. However, the authors noted that more extensive, double-blinded, randomized controlled studies with extended follow-up periods are necessary to learn more about the role of TXA in rosacea treatment and other dermatological conditions. 

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Is tranexamic acid safe for sensitive skin?

Tranexamic acid is considered generally safe for all skin types. However, it is a good idea to do a patch test before using a tranexamic acid product on your face, especially if you have super sensitive skin. Apply tranexamic acid on the inside of your wrist and observe the area for side effects before using it on your face.

Can I use tranexamic acid serum every day?

Most people can use tranexamic acid serum every day. However, this ingredient can cause skin irritation. People with very sensitive skin should start by including tranexamic acid in their skincare routine a couple of times a week, and slowly increase the frequency of use as their skin adjusts to it.

How long does tranexamic acid take to lighten skin?

It can take 8-12 weeks of regular use of tranexamic acid skin care products before you see a noticeable difference in skin tone and brightness.

Is tranexamic acid better than vitamin C?

Both tranexamic acid and vitamin C are effective and safe treatments for all skin types, but tranexamic acid may be slightly more effective. 

A randomized controlled study was done comparing microneedling with vitamin C and microneedling with tranexamic acid for treating hyperpigmentation in people with melasma. Tranexamic acid was found to produce greater improvement in skin discoloration and better patient satisfaction.

Is tranexamic acid better than retinol for hyperpigmentation?

Both retinol and tranexamic acid have brightening effects. Retinol is considered the gold standard treatment for anti-aging. Either retinol or tranexamic acid might work better for you. Some skincare products contain both active ingredients. 

What should you not use with tranexamic acid on your skin?

It’s important to check labels of skincare products before introducing tranexamic acid into your skin care routine. Avoid using other actives (brightening agents) such as azelaic acid, kojic acid, hyaluronic acid, alpha arbutin, and licorice root at the same time. Using multiple different acids can increase the risk of skin irritation, dryness, and flaking.

Evidence suggests that tranexamic acid works well with skincare ingredients like vitamin C and retinol. But it’s a good idea to introduce skincare ingredients one at a time so that you’ll know if a particular ingredient does not agree with your skin. 

Read Next: “Retinol Vs. Tretinoin: What's The Difference?”

If you have a personal or family history of skin conditions such as rosacea, melasma, or chronic urticaria, consult your healthcare professional, ideally a board-certified dermatologist, before using tranexamic acid for skin improvement.