How should I take bupropion (Wellbutrin XL)?

Take this medication exactly as prescribed. Follow all directions on the prescription label and any medication guides if provided. Never take a larger or smaller amount than the prescribed dose; taking too much bupropion can cause seizures. 

You should not discontinue bupropion suddenly; sudden discontinuation of bupropion can cause uncomfortable withdrawal symptoms. Unless you have seizures while taking bupropion, tell your doctor, and bupropion should be discontinued immediately.

If you take bupropion for seasonal depression, your doctor will tell you how to safely stop using it in the early spring. 

Do not cut, crush, break, or chew bupropion extended-release tablets. You should swallow the tablet whole.

Instructions for the use of bupropion (Zyban) for smoking cessation:

• You may continue to smoke for about 1 week after you start bupropion (Zyban)
• Set a quit date during the second week of bupropion (Zyban)
• Talk to your healthcare provider if you have trouble quitting after you have used bupropion (Zyban) for at least 7 to 12 weeks.
• If your doctor prescribes you nicotine replacement therapy such as nicotine patches or gum to help you quit smoking, you may start using the nicotine replacement product (patches or gums) on the same day you quit smoking or using tobacco products. 

With smoking cessation, you may have nicotine withdrawal symptoms; you may have these symptoms with or without bupropion (Zyban). Symptoms of nicotine withdrawal include trouble concentrating, sleeping problems, increased appetite, weight gain, slowed heart rate, anxiety, restlessness, feeling depressed, angry, frustrated, irritated, and having the urge to smoke. 

Smoking cessation may cause new or worsen existing mental illnesses, such as depression. Tell your doctor if you experience any change in your mood or behavior. 

Bupropion may cause false positive drug screening tests. If you have to do a urine drug screening, let your doctor or laboratory personnel know that you take bupropion.

Missed dose: Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not double the amount or take more than prescribed to make up for the missed dose. Let your doctor or pharmacist know immediately if you have missed more than one dose or are unsure about what to do.

Storage: Keep the medication in its original container; keep it tightly closed, out of reach of children, pets, and other people. Like any other prescription medication, bupropion should not be shared with anyone. Many people store their medications in the bathroom; this is not recommended due to moisture and heat.

Unused medicine: Like other prescription medications, do not consume bupropion after the expiration date. This prescription drug is intended for your use only. Unneeded medicines should be disposed of appropriately to prevent children, pets, and other people from getting to them. Your local pharmacy can provide information about medication drug take-back programs. You can also learn more about proper medication disposal.

NOTE: This sheet is a summary and may not contain all possible information. If you have more questions or concerns about bupropion, talk to your pharmacist or doctor to ensure that this information applies to you or your family member.

Discounted prices for bupropion start at $25.56

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