This medicine may interact with the following medications:

-antiviral medications for HIV or AIDS
-aprepitant
-boceprevir
-calcium channel blockers like diltiazem and verapamil
-certain antibiotics like clarithromycin, erythromycin, and troleandomycin
-certain medicines for fungal infections like fluconazole, ketoconazole, itraconazole, posaconazole, and voriconazole
-certain medicines for seizures like carbamazepine and phenytoin
-certain medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
-ciprofloxacin
-clotrimazole
-conivaptan
-crizotinib
-cyclosporine
-dronedarone
-enzalutamide
-fluvoxamine
-grapefruit juice
-idelalisib
-imatinib
-methotrexate
-mitotane
-nefazodone
-rifampin
-St. John''s wort

They need to know if you have any of these conditions:

-bleeding disorders
-high blood pressure
-history of irregular heartbeat
-infection including hepatitis B virus infection
-liver disease
-recent surgery
-take medicines that treat or prevent blood clots
-an unusual or allergic reaction to acalabrutinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

You may need blood work done while you are taking this medicine.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body''s ability to fight infections. Try to avoid being around people who are sick.
If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine. Tell your dentist and dental surgeon that you are taking this medicine. You should not have major dental surgery while on this medicine. See your dentist to have a dental exam and fix any dental problems before starting this medicine.
Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen.
Do not become pregnant while taking this medicine or for at least 1 week after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after stopping it.

Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.