Do not take this medication with any of the following medications:

-sacubitril; valsartan
This medicine may also interact with the following:

-amphotericin B
-barbiturates like phenobarbital
-blood pressure medicines
-calcium supplements
-corticosteroids like prednisone
-diabetic medications
-digoxin
-diuretics, especially potassium-sparing diuretics like triamterene, spironolactone or amiloride
-lithium
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-medicines for angina like nitroglycerin
-medicines that treat or prevent blood clots like warfarin
-medicines used to treat gout
-methenamine
-NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
-potassium salts or potassium supplements
-prescription pain medicines
-skeletal muscle relaxants like tubocurarine
-some cholesterol-lowering medications like cholestyramine or colestipol

They need to know if you have any of these conditions:

-bone marrow disease
-decreased urine
-diabetes
-heart or blood vessel disease
-if you are on a special diet like a low salt diet
-immune system problems, like lupus
-kidney disease
-liver disease
-previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat
-recent heart attack or stroke
-an unusual or allergic reaction to captopril, hydrochlorothiazide, sulfa drugs, other medicines, insect venom, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care provider for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care provider what your blood pressure should be and when you should contact him or her. Call your doctor or health care provider if you notice an irregular or fast heartbeat.
You must not get dehydrated. Ask your doctor or health care provider how much fluid you need to drink a day. Check with him or her if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.
Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care provider or pharmacist for more information.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.
This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.
Avoid salt substitutes unless you are told otherwise by your doctor or health care provider.
Talk to your health care professional about your risk of skin cancer. You may be more at risk for skin cancer if you take this medicine.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care provider for advice. Some ingredients may increase your blood pressure.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture. Keep the container tightly closed. Throw away any unused drug after the expiration date.