Carbidopa-Levodopa

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Apr 25, 2023

Pros & Cons


Carbidopa-Levodopa (Sinemet) Pros and Cons

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  • Carbidopa and levodopa are the first choice medications for treating patients with Parkinson’s disease.
  • They are available in many dosage forms and dosage strengths for convenience and ease during the dose adjustment period.
  • This medicine is available in a lower-cost generic version.

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  • You need to take carbidopa and levodopa multiple times a day.
  • This medicine can make you very sleepy, causing sudden sleepiness during regular daily activities.
  • Carbidopa/levodopa may not work well for people with advanced Parkinson’s disease.
  • Concomitant therapy with other drugs can lead to interactions and adverse effects.