Warnings
Celecoxib Risks, Warnings, and Complications
Celecoxib can cause serious side effects in certain people. Talk to your doctor or pharmacist about other treatment options if you are at increased risk of complications from celecoxib use.
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Precautions Before Starting Celecoxib
Tell your doctor if you have ever had an allergic reaction to celecoxib; any of the active or inactive ingredients in celecoxib capsules; other nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen (Advil, Motrin) or naproxen (Naprosyn, Aleve); sulfa drugs; or any other medications. Your pharmacy can give you a list of ingredients.
Give your doctor a complete medical history. Celecoxib may not be right for people with certain medical conditions such as asthma, frequent stuffy or runny nose, nasal polyps, swelling of the legs or feet, heart failure, kidney disease, or liver disease.
Give your doctor and pharmacist a complete list of your medications, including prescription drugs, over-the-counter medicines, vitamins, supplements, and herbal products. This can help avoid possible drug interactions.
Tell your doctor if you are pregnant, could be pregnant, are planning a pregnancy, or are breastfeeding. Celecoxib can be harmful to an unborn baby if it is taken after 20 weeks of pregnancy. This medication can pass into breast milk and may be harmful to a breastfeeding infant.
Precautions During Use of Celecoxib
Keep all your doctors’ appointments and lab appointments while taking Celebrex (celecoxib).
Call your doctor if you become pregnant while taking celecoxib.
Tell all your doctors you are on celecoxib before any surgery, including dental procedures.
Celecoxib Drug Interactions
Certain other drugs can affect how celecoxib works. Possible interactions between celecoxib and other medicines can increase the risk of severe adverse effects. The following medications can have possible interactions with celecoxib:
- Anticoagulants such as warfarin (Coumadin, Jantoven)
- Aspirin
- Other NSAIDs such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn)
- Oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos)
- Selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft)
- Serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR)
- Angiotensin-converting enzyme (ACE) inhibitors such as captopril, benazepril (Lotensin, in Lotrel), enalapril (Epaned, Vasotec, in Vaseretic), lisinopril (Qbrelis, in Zestoretic), fosinopril, moexipril (Univasc), quinapril (Accupril, in Quinaretic), perindopril (Aceon, in Prestalia), trandolapril (in Tarka), and ramipril (Altace)
- Angiotensin receptor blockers such as irbesartan (Avapro, in Avalide), candesartan (Atacand, in Atacand HCT), losartan (Cozaar, in Hyzaar), eprosartan, olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), valsartan (Diovan, in Entresto, in Exforge HCT), and telmisartan (Micardis, in Micardis HCT, in Twynsta)
- Beta blockers such as metoprolol (Lopressor, Kapspargo Sprinkle, Toprol XL, in Dutoprol), atenolol (Tenormin, in Tenoretic), nadolol (Corgard, in Corzide), labetalol (Trandate), and propranolol (Hemangeol, Inderal, Innopran)
- ADHD medicines like atomoxetine (Strattera)
- Organ transplant medicines like cyclosporine (Gengraf, Neoral, Sandimmune)
- Heart medicines like digoxin (Lanoxin)
- Diuretics or water pills
- Antifungals like fluconazole (Diflucan)
- Psychiatric medicines like lithium (Lithobid)
- Cancer medications like methotrexate (Reditrex, Rasuvo, Otrexup, Trexall) and pemetrexed (Pemfexy, Alimta)
The above list may not describe all possible interactions of celecoxib. Give your doctor or pharmacist a complete list of your medications, including prescription drugs, OTC medications, dietary supplements, and herbal remedies. Also, tell your healthcare professional if you smoke, drink alcohol, or use recreational drugs because some of these substances can cause serious health complications when used with prescription medications.
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