Do not take this medicine with any of the following medications:
-aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:
-carbamazepine
-certain antibiotics used to treat infections
-certain barbiturates used for inducing sleep or treating seizures
-grapefruit juice
-medicines for fungus infections like itraconazole and ketoconazole
-raloxifene or tamoxifen
-rifabutin, rifampin, or rifapentine
-ritonavir
-St. John''s Wort

They need to know if you have any of these conditions:
-abnormal vaginal bleeding
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-dementia
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high level of calcium in the blood
-hysterectomy
-kidney disease
-liver disease
-migraine headaches
-protein C deficiency
-protein S deficiency
-stroke
-systemic lupus erythematosus (SLE)
-tobacco smoker
-an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.

Contact with water while you are swimming, using a sauna, bathing, or showering may cause the patch to fall off. If your patch falls off reapply it. If you cannot reapply the patch, apply a new patch to another area and continue to follow your usual dose schedule.

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.