Dextroamphetamine Sulfate

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Dec 17, 2024

dextroamphetamine sulfate Drug Details (Generic)


Common Brands:

Zenzedi, Dexedrine

Availability:

Prescription only

Therapeutic Class:

Central nervous system stimulants

Forms:

Tablet, extended-release capsule, liquid

Administration:

By mouth

Therapeutic Uses:

  • Attention deficit hyperactivity disorder (ADHD)
  • Narcolepsy

Controlled Status:

Schedule II controlled substance


Dextroamphetamine Sulfate (Zenzedi) Drug Class

Dextroamphetamine sulfate (deks-troe-am-fet-ah-meen sul-fayt) is a central nervous system stimulant.

Dextroamphetamine Sulfate (Zenzedi) Age Range

Dextroamphetamine sulfate is approved for the treatment of attention deficit hyperactivity disorder (ADHD) in children ages 3 to 16 years. Dextroamphetamine sulfate is also used to treat narcolepsy in adults and children. This medication is not recommended for pediatric patients under 3 years of age.

Zenzedi Drug Details (Brand)


Generic Name:

Therapeutic Class:

Narcolepsy Agents

Availability:

Rx

Common Brands:

Form:

Oral tablet

DEXTROAMPHETAMINE (dex troe am FET a meen) treats attention-deficit hyperactivity disorder (ADHD). It works by improving focus and reducing impulsive behavior. It may also be used to treat narcolepsy. It works by promoting wakefulness. It belongs to a group of medications called stimulants.

ProCentra Drug Details (Brand)


Generic Name:

Therapeutic Class:

ADHD Agents, Stimulant, and other Psychostimulants

Availability:

Rx

Common Brands:

Form:

Oral solution

DEXTROAMPHETAMINE (dex troe am FET a meen) treats attention-deficit hyperactivity disorder (ADHD). It works by improving focus and reducing impulsive behavior. It may also be used to treat narcolepsy. It works by promoting wakefulness. It belongs to a group of medications called stimulants.

Dexedrine Spansule Drug Details (Brand)


Generic Name:

Therapeutic Class:

ADD and ADHD

Availability:

Rx

Common Brands:

Form:

Oral capsule, extended release

DEXTROAMPHETAMINE (dex troe am FET a meen) is used to treat attention-deficit hyperactivity disorder (ADHD). It may also be used for narcolepsy. Federal law prohibits giving this medicine to any person other than the person for whom it was prescribed. Do not share this medicine with anyone else.

dextroamphetamine sulfate Uses (Generic)


Dextroamphetamine Sulfate (Zenzedi) Uses

Dextroamphetamine sulfate is a stimulant prescription medication for treating ADHD (attention deficit hyperactivity disorder) in children 3 to 16 years of age. It helps to control ADHD symptoms such as impulsivity, hyperactivity, and attention problems. The medicine is used as part of a total treatment program for ADHD, including behavior therapy, social skills training, parent training, and educational support.

Dextroamphetamine sulfate is also used to treat a sleep disorder called narcolepsy, which is characterized by sudden attacks of sleepiness and excessive daytime drowsiness.

There may be other uses of dextroamphetamine sulfate—your doctor or health system pharmacists can give you further drug information.

Dextroamphetamine Sulfate (Zenzedi) Mechanism of Action

Dextroamphetamine sulfate works by regulating the levels of certain natural substances in the brain that control attention and focus. Scientists believe that a change in the levels of these natural chemicals causes the central nervous system dysfunction responsible for ADHD symptoms.

Dextroamphetamine Sulfate (Zenzedi) Doses

Dextroamphetamine sulfate comes in the following dosage forms:

  • Zenzedi (dextroamphetamine sulfate tablets, USP): 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, 30 mg.
  • Dextroamphetamine sulfate extended-release capsules: 5 mg, 10 mg, and 15 mg.
  • Dextroamphetamine sulfate oral solution: 5 mg/5 mL.

The usual dose of dextroamphetamine sulfate is as follows:

For Attention Deficit Disorder with Hyperactivity

  • In children 3 to 5 years of age: An initial dose of 2.5 mg daily, which may be increased by 2.5 mg per day at weekly intervals. 
  • In children 6 to 17 years of age: An initial dose of 5 mg once or twice daily, which may be increased by 5 mg per day at weekly intervals.

Note: The dose can be increased until maximal dextroamphetamine plasma concentrations and optimum clinical response are achieved (control of the pediatric patient’s symptoms of ADHD). A total daily dose of more than 40 mg is needed only rarely. 

For Narcolepsy

Usual dose range of dextroamphetamine sulfate for treating narcolepsy in adults ranges between 5 mg and 60 mg per day, given in divided doses. 

Dextroamphetamine sulfate may be used to treat narcolepsy in children 3 years of age and older, if needed. However, narcolepsy is uncommon in children under 12 years of age. 

  • The recommended initial dose for pediatric patients between 6 and 12 years of age is 5 mg daily, which can be increased by 5 mg per day at weekly intervals until the optimum response is achieved. 
  • In patients 12 years of age and older, the starting dose is 10 mg daily, which may be increased by 10 mg per day at weekly intervals until optimum clinical response is achieved.

Note: The dose of dextroamphetamine sulfate may need to be reduced if bothersome side effects like insomnia or loss of appetite occur. 

dextroamphetamine sulfate Directions (Generic)


How To Use Dextroamphetamine Sulfate (Zenzedi)

Dextroamphetamine tablets, extended-release capsules, and liquid are taken by mouth 1-3 times a day, as prescribed, with or without food. The dosing frequency of the tablets is usually taken 2-3 times a day, extended-release capsules once daily, and oral liquid twice daily. Do not cut, crush, chew, or open the extended release capsule. Use a dose measuring cup to measure liquid medicine.

Try to take the medication at around the same times every day. Take the first dose upon awakening and space out additional doses at 4-6 hour intervals. Do not take dextroamphetamine sulfate close to bedtime as it can cause sleep problems.

Read the prescription label and follow your doctor’s dosing instructions carefully. Do not change the dose or dosing frequency without your doctor’s approval. Your doctor will likely start you on a low dose of dextroamphetamine sulfate and increase the dose gradually at weekly intervals. Your provider may discontinue treatment with dextroamphetamine sulfate periodically to evaluate whether your symptoms return and whether you need to continue taking the medicine.

Missed dose: If you miss a dose of dextroamphetamine sulfate, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and take the next dose according to your regular dosing schedule. Do not take a double dose or extra medicine to make up for a missed dose.

Storage: Store dextroamphetamine sulfate at room temperature (between 15-30° C or 59-86° F) away from moisture, heat, and direct light in its original container, tightly closed. Do not store medications in the bathroom where they can be exposed to moisture and heat. Keep all medications safely out of reach of children and pets.

Unused medicine: Unused dextroamphetamine sulfate should be disposed of in a way that children, other people, and pets cannot get to them. Do not throw dextroamphetamine sulfate in the trash or flush it down the toilet. The best way to dispose of expired or unneeded dextroamphetamine sulfate is through a drug take-back program or your local waste disposal company. Learn more about proper medication disposal

NOTEThis medication guide is a summary and may not contain all possible drug information on dextroamphetamine sulfate. The information contained here may not be up-to-date. This sheet is for information purposes only. If you have questions about dextroamphetamine sulfate, talk to your doctor for medical advice.


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Zenzedi Directions (Brand)


How should I use Zenzedi?

Take this medication by mouth with water. Take it as directed on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 3 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of Zenzedi contact a poison control center or emergency room at once. NOTE: Zenzedi is only for you. Do not share Zenzedi with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

ProCentra Directions (Brand)


How should I use ProCentra?

Take this medication by mouth with water. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 6 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of ProCentra contact a poison control center or emergency room at once. NOTE: ProCentra is only for you. Do not share ProCentra with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Dexedrine Spansule Directions (Brand)


How should I use Dexedrine Spansule?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor''s advice. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of Dexedrine Spansule contact a poison control center or emergency room at once. NOTE: Dexedrine Spansule is only for you. Do not share Dexedrine Spansule with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

dextroamphetamine sulfate Side Effects (Generic)


Dextroamphetamine Sulfate Side Effects

Possible side effects of dextroamphetamine sulfate are listed below. Call your doctor if the adverse effects are severe or continue after a few days.

  • Headache
  • Bad taste in the mouth
  • Dry mouth
  • Decreased appetite and weight loss
  • Constipation
  • Changes in libido (sex drive) or sexual ability
  • Erectile dysfunction, frequent or prolonged erections

Some of the side effects of dextroamphetamine sulfate are more serious. Call your doctor right away or seek emergency medical attention if you develop the following symptoms:

  • Excessive fatigue
  • Problems with speech
  • Lightheadedness or dizziness
  • Seizures
  • Weakness, numbness, tingling in an arm or leg
  • Mood changes
  • Delusions (believing things that are not true)
  • Paranoia (unusual suspicions)
  • Hallucinations (seeing, hearing, or feeling things that are not there)
  • Mania (abnormal excitement)
  • Agitation, fever, confusion, sweating, shivering, fast heartbeat, severe muscle stiffness, muscle twitching, poor coordination, nausea, vomiting, diarrhea
  • Abnormal movements
  • Tics (uncontrollable sounds or movements) 
  • Vision changes such as blurred vision
  • Skin rash, hives, itching
  • Pale or blue-tinged fingers or toes
  • Unexplained wounds on the fingers or toes
  • Burning, tingling, pain in the hands and feet

The above list may not include all the potentially dangerous or bothersome adverse reactions of dextroamphetamine sulfate. Contact your healthcare provider if the adverse reactions are unusual or severe or they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Dextroamphetamine sulfate (Zenzedi) Overdose: In case of an overdose of dextroamphetamine sulfate, call your doctor immediately. You can also call your local poison control center or the national poison control center at 1-800-222-1222. Overdose symptoms may include restlessness, tiredness, muscle weakness, uncontrolled shaking, dark colored urine, irregular heartbeat, fast breathing, fever, confusion, aggression, panic, hallucinations, depression, blurred vision, dizziness, fainting, stomach upset, stomach cramps, nausea, vomiting, diarrhea, convulsions, and loss of consciousness.

Source: FDA


Zenzedi Side Effects (Brand)


What side effects may I notice from receiving Zenzedi?

Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
-Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
-Increase in blood pressure
-Irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizure, chills, vomiting, diarrhea, which may be signs of serotonin syndrome
-Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
-Prolonged or painful erection
-Raynaud syndrome—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red
-Seizures
-Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Dry mouth
-Headache
-Loss of appetite with weight loss
-Nausea
-Stomach pain
-Trouble sleeping

This list may not describe all possible side effects for Zenzedi. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

ProCentra Side Effects (Brand)


What side effects may I notice from receiving ProCentra?

Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
-Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
-Increase in blood pressure
-Irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizure, chills, vomiting, diarrhea, which may be signs of serotonin syndrome
-Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
-Prolonged or painful erection
-Raynaud syndrome—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red
-Seizures
-Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Dry mouth
-Headache
-Loss of appetite with weight loss
-Nausea
-Stomach pain
-Trouble sleeping

This list may not describe all possible side effects for ProCentra. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

Dexedrine Spansule Side Effects (Brand)


What side effects may I notice from receiving Dexedrine Spansule?

Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue-changes in vision
-chest pain or chest tightness
-confusion, trouble speaking or understanding
-fast, irregular heartbeat
-fingers or toes feel numb, cool, painful
-hallucination, loss of contact with reality
-high blood pressure
-males: prolonged or painful erection
-seizures
-severe headaches
-shortness of breath
-suicidal thoughts or other mood changes
-trouble walking, dizziness, loss of balance or coordination
-uncontrollable head, mouth, neck, arm, or leg movements

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-anxious
-headache
-loss of appetite
-nausea, vomiting
-trouble sleeping
-weight loss

This list may not describe all possible side effects for Dexedrine Spansule. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Source: FDA

dextroamphetamine sulfate Warnings (Generic)


Dextroamphetamine Sulfate (Zenzedi) Risks, Warnings, and Complications


Dextroamphetamine sulfate can cause or worsen serious health problems in some people. Discuss other medications for attention deficit hyperactivity disorder or narcolepsy with your doctor or pharmacist if you are at an increased risk of adverse effects from this drug. Some of the risks of taking dextroamphetamine sulfate include:

  • POTENTIAL FOR ABUSE AND ADDICTION: Dextroamphetamine sulfate is a federally controlled substance with a high potential for drug abuse, misuse, drug dependence, and addiction. This medication can be habit-forming and carries the risk of developing a substance use disorder and addiction. Some people abuse prescription medicines and may use amphetamines for non-medical uses or sell or distribute these drugs illegally. Misuse and abuse of CNS stimulants such as dextroamphetamine sulfate is associated with a high risk of overdose and death. 

    Before prescribing dextroamphetamine sulfate, your doctor will ask about a personal or family history of substance use disorders (abuse, misuse, and addiction to alcohol, prescription medicines, or street drugs). 

    Do not take a higher dose or more frequent doses of dextroamphetamine sulfate than prescribed. Never obtain the drug from illegal sources or share your prescribed medication with others. Do not use the drug in unapproved ways, such as snorting or injecting it. Store dextroamphetamine sulfate in a safe place, preferably under lock. 

  • RISK IN PATIENTS WITH HEART DISEASE: There are reports of sudden death in people with severe heart disease, such as structural cardiac abnormalities, after treatment with CNS stimulants such as dextroamphetamine sulfate at recommended dosages for ADHD treatment.

    Tell your doctor if you have a history of heart problems, including structural abnormalities, cardiomyopathy, cardiac arrhythmias, coronary artery disease, or other serious forms of heart disease. 

    Seek emergency medical care for symptoms of serious cardiovascular adverse events such as chest pain, chest pressure, or difficulty breathing during dextroamphetamine sulfate treatment.

  • INCREASED BLOOD PRESSURE AND HEART RATE: Taking stimulant medications, including dextroamphetamine sulfate, can lead to an increase in blood pressure and heart rate. Your doctor will monitor your or your child’s blood pressure and heart rate while on this medication.

  • ADVERSE PSYCHIATRIC REACTIONS: CNS stimulants can cause worsening mental symptoms in people with pre-existing psychotic disorders. In addition to psychotic symptoms, these drugs can also cause worse bipolar illness. They may trigger manic or mixed episodes in people with bipolar disorder. 

    Taking dextroamphetamine sulfate at the recommended doses can cause new psychotic or manic symptoms in some people. These may include delusions, paranoia, hallucinations, or mania. You may need to discontinue treatment with dextroamphetamine sulfate if these mental and behavioral effects occur.

    Given that amphetamines produce mental symptoms, it is important that prior to starting dextroamphetamine sulfate treatment, you tell your doctor about any personal or family history of bipolar illness, depression, psychosis, or suicide attempts. 

  • LONG-TERM SUPPRESSION OF GROWTH IN CHILDREN: Dextroamphetamine sulfate is a stimulant prescription medicine that can cause weight loss and slow growth in children. Your child’s healthcare provider will monitor growth (height and weight) carefully during treatment with this drug. They may advise discontinuing treatment if your child is not gaining weight or height as expected for age.

  • SEIZURES: Amphetamine CNS stimulation can lower the seizure threshold in people with a history of seizure disorders or abnormal EEG (abnormal brain wave test). Very rarely, this can also happen in people with no prior history of seizures or EEG abnormalities. You will need to stop treatment with dextroamphetamine sulfate if you develop seizures. 

  • PERIPHERAL VASCULAR DISEASE: Dextroamphetamine sulfate tablets, USP, can cause peripheral vasculopathy (circulation problems), including Raynaud's phenomenon. Call your doctor without delay if you develop pale or blue fingers or toes or unexplained wounds on your fingers or toes. These symptoms usually improve after the dose is reduced or the drug is discontinued. 

  • SEROTONIN SYNDROME: People receiving dextroamphetamine sulfate can develop a potentially life-threatening condition called serotonin syndrome. Serotonin syndrome occurs due to too much serotonin, a natural chemical in the brain. Risk factors include concomitant serotonergic drug use. Taking certain other drugs such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), triptans, fentanyl, lithium, tramadol, buspirone, tryptophan, and St. John's Wort can increase the risk of serotonin syndrome. 

    Give your doctor a complete list of your medications before starting treatment. Seek emergency medical care if you develop signs and symptoms of serotonin syndrome, such as mental status changes (agitation, confusion, delirium, hallucinations, or loss of consciousness), fast heartbeat, changes in blood pressure, sweating, flushing, dizziness, fever, tremors, muscle rigidity, muscle twitching, incoordination, convulsions, nausea, vomiting, or diarrhea. Discontinuation of dextroamphetamine sulfate and concomitant serotonergic agents immediately is necessary if this serious complication develops.

  • TICS: Dextroamphetamine sulfate and other CNS stimulants can cause motor and verbal tics and worsening symptoms in people with Tourette's syndrome. Tell your healthcare provider if there is a personal or family history of tics or Tourette's syndrome before starting dextroamphetamine sulfate


Precautions Before Starting Dextroamphetamine Sulfate (Zenzedi)

Tell your doctor if you have had allergic reactions to dextroamphetamine sulfate, any of the active or inactive ingredients in dextroamphetamine sulfate formulations, other medications prescribed for ADHD, or any other drugs. Your pharmacy can give you a list of ingredients.

To avoid possible interactions between dextroamphetamine sulfate and other medicines, give your doctor and pharmacist a full list of your or your child’s medicines, including prescription medications, over-the-counter medicines, vitamins, dietary supplements, and herbal supplements.

Give your healthcare provider a complete medical history. Dextroamphetamine sulfate may not be safe for people with certain health conditions, such as glaucoma, hyperthyroidism, a family history of sudden death due to cardiac causes, personal or family history of mental illness including depression, bipolar illness, or suicide attempts, recent heart attack, heart defects, high blood pressure, irregular heartbeat, tics or Tourette’s syndrome, and seizure disorders or abnormal EEG.

Tell your doctor if you are pregnant, could be pregnant, plan to get pregnant, or are breast-feeding.

Talk to your doctor about the benefits versus risks of taking dextroamphetamine sulfate if you are 65 years of age or older. There may be other safer medications available.

Precautions During Use of Dextroamphetamine Sulfate (Zenzedi)

Keep all your medical and lab appointments while on dextroamphetamine sulfate. Your doctor will adjust your dose based on your response to the medicine.

Dextroamphetamine sulfate can cause lightheadedness, dizziness, drowsiness, and coordination problems. Be careful while driving or operating machinery until you know how the medicine affects you.

Tell your doctor if you become pregnant while on dextroamphetamine sulfate. Do not breast-feed while on this drug.

Tell all your healthcare providers you are on dextroamphetamine sulfate before any surgical procedure, including dental surgery.

Dextroamphetamine sulfate should be used to treat ADHD as part of a total treatment plan which includes behavior therapy, counseling, training, and medications. Follow your doctor’s recommendations for treating ADHD to get the maximum benefits from this drug.

Dextroamphetamine Sulfate (Zenzedi) Drug Interactions

Taking certain other medicines with dextroamphetamine sulfate can affect how the medications work. Possible drug interactions can increase the risk of severe adverse effects. The following medications can have interactions with dextroamphetamine sulfate:

  • Monoamine oxidase (MAO) inhibitors such as linezolid (Zyvox), isocarboxazid (Marplan), selegiline (Eldepryl, Emsam, Zelapar), phenelzine (Nardil), and tranylcypromine (Parnate) - the intravenous medicine methylene blue is also a monoamine oxidase inhibitor
  • Herbal supplements such as St. John's wort and tryptophan
  • Dietary supplements such as glutamic acid (L-glutamine), vitamin C or ascorbic acid, sodium bicarbonate (baking soda), sodium acid phosphate
  • Allergy medicines such as cetirizine, loratadine, fexofenadine, diphenhydramine, chlorpheniramine
  • Antacids and heartburn medications such as omeprazole (Prilosec)

The above list may not include all the potential interactions of dextroamphetamine sulfate. Give your doctor or pharmacist a complete list of your medications, including prescription drugs, nonprescription drugs, nutritional supplements, and herbal remedies. Also, tell your healthcare professional if you smoke, drink alcohol, or use illegal drugs because some of these substances can cause serious health complications when used with prescription medications.

Zenzedi Warnings (Brand)


What may interact with Zenzedi?

Do not take this medication with any of the following:
-Linezolid
-MAOIs, such as Marplan, Nardil, and Parnate
-Methylene blue
This medication may also interact with the following:
-Acetazolamide
-Alcohol
-Ascorbic acid
-Certain medications for depression, anxiety, or other mental health conditions
-Certain medications for migraines, such as sumatriptan
-Guanethidine
-Opioids
-Reserpine
-Sodium bicarbonate
-St. John's wort
-Thiazide diuretics, such as chlorothiazide
-Tryptophan

What should I tell my health care provider before I take Zenzedi

They need to know if you have any of these conditions:
-Anxiety or panic attacks
-Circulation problems in fingers and toes (Raynaud disease)
-Glaucoma
-Heart attack
-Heart disease
-High blood pressure
-History of substance use disorder
-Kidney disease
-Liver disease
-Mental health conditions
-Seizures
-Stroke
-Suicidal thoughts, plans, or attempt by you or a family member
-Thyroid disease
-Tourette syndrome
-An unusual or allergic reaction to dextroamphetamine, other amphetamines, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

What should I watch for while using Zenzedi?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
This medication requires a new prescription from your care team every time it is filled at the pharmacy.
This medication can be abused and cause your brain and body to depend on it after high doses or long term use. Your care team will assess your risk and monitor you closely during treatment.
Long term use of this medication may cause your brain and body to depend on it. You may be able to take breaks from this medication during weekends, holidays, or summer vacations. Talk to your care team about what works for you. If your care team wants you to stop this medication permanently, the dose may be slowly lowered over time to reduce the risk of side effects.
Tell your care team if this medication loses its effects, or if you feel you need to take more than the prescribed amount. Do not change your dose without talking to your care team.
Do not take this medication close to bedtime. It may prevent you from sleeping.
Loss of appetite is common when starting this medication. Eating small, frequent meals or snacks can help. Talk to your care team if appetite loss persists. Children should have height and weight checked often while taking this medication.
Tell your care team right away if you notice unexplained wounds on your fingers and toes while taking this medication. You should also tell your care team if you experience numbness or pain, changes in the skin color, or sensitivity to temperature in your fingers or toes.
Contact your care team right away if you have an erection that lasts longer than 4 hours or if it becomes painful. This may be a sign of a serious problem and must be treated right away to prevent permanent damage.

Where should I keep my medicine?

Keep out of the reach of children and pets. This medication can be abused. Keep it in a safe place to protect it from theft. Do not share it with anyone. It is only for you. Selling or giving away this medication is dangerous and against the law.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light and moisture. Keep container tightly closed. Get rid of any unused medication after the expiration date.
This medication may cause harm and death if it is taken by other adults, children, or pets. It is important to get rid of the medication as soon as you no longer need it or it is expired. You can do this in two ways:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

ProCentra Warnings (Brand)


What may interact with ProCentra?

Do not take this medication with any of the following:
-Linezolid
-MAOIs, such as Marplan, Nardil, and Parnate
-Methylene blue
This medication may also interact with the following:
-Acetazolamide
-Alcohol
-Ascorbic acid
-Certain medications for depression, anxiety, or other mental health conditions
-Certain medications for migraines, such as sumatriptan
-Guanethidine
-Opioids
-Reserpine
-Sodium bicarbonate
-St. John's wort
-Thiazide diuretics, such as chlorothiazide
-Tryptophan

What should I tell my health care provider before I take ProCentra

They need to know if you have any of these conditions:
-Anxiety or panic attacks
-Circulation problems in fingers and toes (Raynaud disease)
-Glaucoma
-Heart attack
-Heart disease
-High blood pressure
-History of substance use disorder
-Kidney disease
-Liver disease
-Mental health conditions
-Seizures
-Stroke
-Suicidal thoughts, plans, or attempt by you or a family member
-Thyroid disease
-Tourette syndrome
-An unusual or allergic reaction to dextroamphetamine, other amphetamines, other medications, foods, dyes, or preservatives
-Pregnant or trying to get pregnant
-Breast-feeding

What should I watch for while using ProCentra?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
This medication requires a new prescription from your care team every time it is filled at the pharmacy.
This medication can be abused and cause your brain and body to depend on it after high doses or long term use. Your care team will assess your risk and monitor you closely during treatment.
Long term use of this medication may cause your brain and body to depend on it. You may be able to take breaks from this medication during weekends, holidays, or summer vacations. Talk to your care team about what works for you. If your care team wants you to stop this medication permanently, the dose may be slowly lowered over time to reduce the risk of side effects.
Tell your care team if this medication loses its effects, or if you feel you need to take more than the prescribed amount. Do not change your dose without talking to your care team.
Do not take this medication close to bedtime. It may prevent you from sleeping.
Loss of appetite is common when starting this medication. Eating small, frequent meals or snacks can help. Talk to your care team if appetite loss persists. Children should have height and weight checked often while taking this medication.
Tell your care team right away if you notice unexplained wounds on your fingers and toes while taking this medication. You should also tell your care team if you experience numbness or pain, changes in the skin color, or sensitivity to temperature in your fingers or toes.
Contact your care team right away if you have an erection that lasts longer than 4 hours or if it becomes painful. This may be a sign of a serious problem and must be treated right away to prevent permanent damage.

Where should I keep my medicine?

Keep out of the reach of children and pets. This medication can be abused. Keep it in a safe place to protect it from theft. Do not share it with anyone. It is only for you. Selling or giving away this medication is dangerous and against the law.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Keep container tightly closed. Get rid of any unused medication after the expiration date.
This medication may cause harm and death if it is taken by other adults, children, or pets. It is important to get rid of the medication as soon as you no longer need it or it is expired. You can do this in two ways:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, pour the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

Dexedrine Spansule Warnings (Brand)


What may interact with Dexedrine Spansule?

Do not take this medicine with any of the following medications:
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-other stimulant medicines for attention disorders, weight loss, or to stay awake

This medicine may also interact with the following medications:
-acetazolamide
-ammonium chloride
-ascorbic acid
-atomoxetine
-caffeine
-certain medicines for blood pressure, heart disease, irregular heart beat
-certain medicines for depression, anxiety, or psychotic disturbances
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-cold or allergy medicines
-glutamic acid
-lithium
-medicines that increase blood pressure like dopamine, dobutamine, ephedrine, or norepinephrine
-meperidine
-methenamine; sodium acid phosphate
-narcotic medicines for pain
-sodium bicarbonate

What should I tell my health care provider before I take Dexedrine Spansule?

They need to know if you have any of these conditions:
-anxiety or panic attacks
-circulation problems in fingers and toes
-glaucoma
-hardening or blockages of the arteries or heart blood vessels
-heart disease or a heart defect
-high blood pressure
-history of a drug or alcohol abuse problem
-history of stroke
-kidney disease
-liver disease
-mental illness
-seizures
-suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
-thyroid disease
-Tourette''s syndrome
-an unusual or allergic reaction to dextroamphetamine, other amphetamines, tartrazine, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using Dexedrine Spansule?

Visit your doctor or health care professional for regular checks on your progress. This prescription requires that you follow special procedures with your doctor and pharmacy. You will need to have a new written prescription from your doctor every time you need a refill.

This medicine may affect your concentration, or hide signs of tiredness. Until you know how this medicine affects you, do not drive, ride a bicycle, use machinery, or do anything that needs mental alertness.

Tell your doctor or health care professional if this medicine loses its effects, or if you feel you need to take more than the prescribed amount. Do not change the dose without talking to your doctor or health care professional.

Decreased appetite is a common side effect when starting this medicine. Eating small, frequent meals or snacks can help. Talk to your doctor if you continue to have poor eating habits. Height and weight growth of a child taking this medicine will be monitored closely.

Do not take this medicine close to bedtime. It may prevent you from sleeping.

If you are going to need surgery, a MRI, CT scan, or other procedure, tell your doctor that you are taking this medicine. You may need to stop taking this medicine before the procedure.

Tell your doctor or healthcare professional right away if you notice unexplained wounds on your fingers and toes while taking this medicine. You should also tell your healthcare provider if you experience numbness or pain, changes in the skin color, or sensitivity to temperature in your fingers or toes.

Where should I keep my medicine?

Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date. Dispose of properly. This medicine may cause accidental overdose and death if it is taken by other adults, children, or pets. Mix any unused medicine with a substance like cat litter or coffee grounds. Then throw the medicine away in a sealed container like a sealed bag or a coffee can with a lid. Do not use the medicine after the expiration date.

dextroamphetamine sulfate Pros & Cons (Generic)


Dextroamphetamine Sulfate (Zenzedi) Pros and Cons

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  • Dextroamphetamine sulfate is available as a lower-cost generic.
  • The extended release capsules only need to be taken once a day.
  • There is a liquid solution for people who have trouble swallowing pills.
  • Safe for children 3 years of age and older.

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  • Dextroamphetamine sulfate is a federally controlled substance and carries a risk of addiction.
  • It can cause sleep problems if you take it close to bedtime.
  • It is not safe for people with serious heart conditions.

dextroamphetamine sulfate Pharmacist Tips (Generic)


Dextroamphetamine Sulfate (Zenzedi) Tips from Pharmacists

  • Take the first dose of dextroamphetamine sulfate upon awakening and space out additional doses every 4-6 hours. Take the last dose several hours before bedtime to avoid sleep problems.

  • Do not cut, crush, chew, or open the dextroamphetamine sulfate extended-release capsules.

  • Use a dose-measuring cup or syringe to measure liquid medicine. Do not use a regular spoon from your kitchen as this can result in wrong dosing.

  • You can take this medicine with or without food, but it’s best to be consistent - either take it with meals or without, the same every day.

  • Avoid drinking alcohol while on dextroamphetamine sulfate. Alcohol can make side effects like dizziness worse.

dextroamphetamine sulfate Rx Savings Tips (Generic)


Dextroamphetamine Sulfate (Zenzedi) Rx Savings Tips

Dextroamphetamine sulfate is a generic medication and is available at significantly lower prices than the brand name. Brand names Zenzedi and Dexedrine and generic dextroamphetamine sulfate contain the same medicine and are equally effective and safe. Like with most medications, the generic version offers better value. A BuzzRx dextroamphetamine sulfate coupon can result in big savings on the brand name and generic forms of the drug. With a BuzzRx discount card, savings card, or discount coupons, the medication could cost you a fraction of retail prices. Dextroamphetamine sulfate may be under $32.00 for 60 tablets of the 10 mg dose at Walmart, Walgreens, Rite Aid, CVS Pharmacy, and other participating pharmacies with a BuzzRx discount card or free coupon. For the biggest discounts on dextroamphetamine sulfate, give the checkout clerk your BuzzRx dextroamphetamine sulfate discount coupon when you drop off your prescriptions.


Lowest Price for Dextroamphetamine Sulfate (Zenzedi)
Brand
$31.84
Generic
$31.84

VIEW DISCOUNTS
Pricing based on most commonly-filled versions. Select the strength and quantity of your medication for the most accurate pricing.

dextroamphetamine sulfate Common Questions (Generic)


Common Questions about Dextroamphetamine Sulfate (Zenzedi)


What is the difference between dextroamphetamine sulfate and Adderall?

Dextroamphetamine sulfate (brand names: Dexedrine, Zenzedi) has only one active ingredient. The ADHD drug Adderall contains both dextroamphetamine and amphetamine salts.



How quickly does dextroamphetamine sulfate start working?

The tablets and oral solution of dextroamphetamine sulfate start working within 30-60 minutes. The extended release capsules start working within 1-2 hours.



How long does Zenzedi last?

Zenzedi (dextroamphetamine sulfate tablets, USP) lasts 4-6 hours and you need to take it 2-3 times a day or every 4-6 hours. The extended release capsules last 6-8 hours and you only need to take it once per day.



Can I drink alcohol while on dextroamphetamine sulfate?

It is best to avoid drinking alcohol while on dextroamphetamine sulfate. Alcohol can make side effects like dizziness worse.



Is dextroamphetamine sulfate safe during pregnancy?

There isn’t enough evidence to say that dextroamphetamine sulfate is safe during pregnancy. CNS stimulants can increase the risk of pregnancy complications. Talk to your doctor about the benefits versus risks of taking this drug if you’re pregnant.



What is the price of dextroamphetamine without insurance?

Without insurance, dextroamphetamine can be as high as $195.94, but with a free BuzzRx prescription discount coupon, you could pay as low as $31.84 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. While generics tend to have the best savings, you can also use your BuzzRx card and coupons to purchase brand-name versions. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescription drugs—whether you have insurance or not.



What is the price of dextroamphetamine with insurance?

Ask your pharmacist or insurance provider for your copay price on dextroamphetamine—Copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins.

You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for dextroamphetamine. When using the BuzzRx lookup tool to find the price of your medicine, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not