Diclofenac Potassium Uses

Diclofenac potassium is used to treat mild to moderate acute pain caused by musculoskeletal conditions, symptoms of osteoarthritis and rheumatoid arthritis, menstrual pain, and migraine headaches. Another salt of diclofenac, diclofenac sodium, is available in extended-release and delayed-release formulations, such as Voltaren XR, to treat osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

There may be additional uses of diclofenac potassium—your doctor or pharmacist can give you further drug information.

Diclofenac Potassium Mechanism of Action

Diclofenac potassium is a non-steroidal anti-inflammatory drug. It works by blocking prostaglandin synthesis in the body. Prostaglandins are natural substances which cause pain and inflammation.

Diclofenac Potassium Doses

Diclofenac potassium is available as a 25-mg liquid filled capsule (Zipsor); a 50-mg immediate-release tablet (Cataflam brand discontinued, generic available); and 50-mg powder for solution (Cambia). 

The usual dose of diclofenac potassium is as follows:

• For mild to moderate musculoskeletal pain: 25 mg four times a day.
• For osteoarthritis: 50 mg 2-3 times a day (for a total daily dose 100 mg to 150 mg).
• For rheumatoid arthritis: 50 mg 3-4 times a day (for a total daily dose 150 mg to 200 mg).
• For dysmenorrhea (menstrual cramps): 50 mg three times a day.
• For migraine attacks: One packet (50 mg) of powder mixed in 1-2 ounces (30-60 mL) of water.

You should use the lowest effective dose of diclofenac potassium for the shortest duration to treat your condition.