Divalproex Sodium ER

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Jul 02, 2024

Pros & Cons


Divalproex (Depakote ER) Pros and Cons

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  • Divalproex can be used alone or in combination with other antiepileptic medications to control seizures.
  • It is available as an extended-release tablet for once-daily dosing.
  • The liquid solution and sprinkle formations are useful for children and adults who have trouble swallowing pills.
  • There is a lower-cost generic available.

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  • You need to get regular blood tests while on divalproex.
  • This medication can help with migraine prevention, but it does not stop a migraine headache after it has begun.
  • It is not safe for use by pregnant women and can cause serious birth defects in the unborn baby.