Do not take this medicine with any of the following medications:

-any medicine that contains efavirenz, emtricitabine, lamivudine, or tenofovir
-disopyramide
-elbasvir; grazoprevir
-rifapentine
-voriconazole

This medicine may also interact with the following medications:

-amiodarone
-artemether; lumefantrine
-atovaquone; proguanil
-cyclosporine
-certain antibiotics like clarithromycin, gentamicin, rifabutin, rifampin
-female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
-medicines for heart rate and blood pressure like diltiazem, felodipine, nicardipine, nifedipine, verapamil
-medicines for cholesterol like atorvastatin, pravastatin, simvastatin
-medicines for depression, anxiety, or psychotic disturbances like bupropion, sertraline
-medicines for fungal infections like ketoconazole, itraconazole, and posaconazole
-medicines for seizures like carbamazepine, phenobarbital, phenytoin
-medicines for viral infections like adefovir, boceprevir, simeprevir, ledipasvir; sofosbuvir, pibrentasvir; glecaprevir, velpatasvir; sofosbuvir, velpatasvir; sofosbuvir; voxilaprevir, cidofovir, acyclovir, valacyclovir, ganciclovir, valganciclovir
-methadone
-NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen
-other medicines for HIV
-red yeast rice
-sirolimus
-tacrolimus
-warfarin

They need to know if you have any of these conditions:

-bone problems
-heart disease
-history of a drug or alcohol abuse problem
-history of depression or other mental illness
-kidney disease
-liver disease
-seizures
-an unusual or allergic reaction to efavirenz, emtricitabine, tenofovir, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or healthcare provider for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your healthcare provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

If you have hepatitis B, talk to your doctor if you plan to stop this medicine. The symptoms of hepatitis B may get worse if you stop this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Avoid alcohol and mood altering (street) drugs while taking this medicine because they can make these side effects worse.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.