Do not take this medicine with any of the following medications:
-nalidixic acid

This medicine may also interact with the following medications:
-calcium supplements
-medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
-vaccines

Talk to your doctor or health care professional before taking any of these medicines:
-acetaminophen
-aspirin
-ibuprofen
-ketoprofen
-naproxen

They need to know if you have any of these conditions:
-blood disorders
-diabetes
-heart disease
-infection (especially a virus infection such as chickenpox, cold sores, or herpes)
-kidney disease
-migraine
-seizures
-an unusual or allergic reaction to estramustine, estrogens, other chemotherapy, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor for checks on your progress. This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body''s ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Both men and women must use effective birth control methods to prevent pregnancy while taking this medicine. Do not become pregnant while taking this medicine. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Women, do not breast-feed an infant while taking this medicine.

Keep out of the reach of children.

Store in the refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Throw away any unused medicine after the expiration date.