Entresto

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Jul 22, 2022

Common Questions


Common Questions about Entresto


What drugs should not be taken with Entresto?

You should not take concomitant antihypertensive drugs with Entresto, such as other angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors. If you have diabetes, you should not take a blood pressure medicine called aliskiren (Tekturna, Tekturna HCT) with Entresto. Other drugs like diuretic therapy and nonsteroidal anti-inflammatory drugs (NSAIDs) may not be safe to take with Entresto. Give your healthcare provider a complete list of all the medicines you are taking or have taken recently to ensure there are no dangerous drug interactions.



How does Entresto help to treat heart failure?

Entresto is a combination medication that contains sacubitril and valsartan. These medicines help to relax the blood vessels, lower blood pressure, improve blood flow, and reduce the workload of the heart. 



Does Entresto make you lose weight?

Entresto helps the body get rid of more fluid and can reduce water weight. On the other hand, heart failure can lead to fluid buildup in the body and weight gain. If you find you have gained weight while on Entresto, talk to your doctor. It could be that your heart failure is not well controlled, and you are gaining water weight. Your doctor may adjust your medications or start you on other heart failure treatments.



Can you eat bananas while on Entresto?

Doctors usually advise limiting consumption of potassium-rich foods while on Entresto. Bananas are a potassium-rich food. Other examples of foods rich in potassium include tomatoes, potatoes, lima beans, papayas, pears, cantaloupes, mangoes, figs, and raisins. Talk to your doctor about how much of these foods are safe for you to consume. Your doctor will probably ask you to avoid potassium supplements and potassium-containing salt substitutes.



Does Entresto help shortness of breath?

Yes, Entresto (sacubitril/valsartan) is an angiotensin receptor neprilysin inhibitor (ARNI) that can slow the progression of heart failure and help with heart failure symptoms like fluid retention and shortness of breath.



What is the price of Entresto without insurance?

Without insurance, Entresto can be as high as $741.47, but with a free BuzzRx prescription discount coupon, you could pay as low as $620.62 for the most common version of this medication. Use the BuzzRx drug price look-up tool to find the lowest discounted price, and be sure to enter the correct dosage, form, and quantity for the most accurate pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not.



What is the price of Entresto with insurance?

Ask your pharmacist or insurance provider for your copay price on Entresto—copay amounts vary depending on the type of insurance plan you have and if there is a deductible to reach before prescription drug coverage begins.

You could save up to 80% on your prescription medication with a free BuzzRx discount coupon for Entresto. When using the BuzzRx lookup tool to find the price of your medication, be sure to enter the correct dosage, form, and quantity to receive the most accurate discounted pricing. It never hurts to ask your pharmacist to try BuzzRx when filling or refilling any of your prescriptions—whether you have insurance or not.