Entresto

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Jul 22, 2022

Pros & Cons


Entresto Pros and Cons

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  • Entresto is the first-choice heart failure treatment for certain types of heart failure, such as severe congestive heart failure with reduced ejection fraction. 
  • It contains two medicines (sacubitril/valsartan) in one convenient pill.
  • This medicine can reduce the risk of hospitalization for heart failure and cardiovascular death in adults with chronic heart failure.
  • Entresto can be given to children over the age of 1 year.

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  • You cannot take Entresto within 36 hours of an ACE inhibitor medicine.
  • It can cause dizziness and lightheadedness. 
  • This medicine is not safe for use during pregnancy.
  • It is available only in tablet form.
  • There is no low-cost generic available yet, and brand name Entresto can be expensive.