-amiodarone
-antacids
-certain antibiotics like rifabutin, rifampin, rifapentine
-certain medicines for cholesterol like atorvastatin and rosuvastatin
-certain medicines for diabetes
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-certain medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
-digoxin
-efavirenz
-St. John''s Wort
-tipranavir
-topotecan
-warfarin

They need to know if you have any of these conditions:

-diabetes (high blood sugar)
-heart disease
-HIV or AIDS
-organ transplant
-other liver disease
-an unusual or allergic reaction to sofosbuvir, velpatasvir, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.
You may need blood work while you are taking this medicine.
If you have had hepatitis B in the past, talk to your health care provider. Taking this medicine could cause the hepatitis B virus to become active again.
This medicine may be given with ribavirin. Ribavirin may cause serious birth defects. If you take this medicine with ribavirin, talk to your health care provider if you think that you or your partner are pregnant or are trying to become pregnant.
This medicine may cause changes in your blood sugar. Ask your health care provider if changes in diet or medicines are needed if you have diabetes.

Keep out of the reach of children and pets.
Store at room temperature below 30 degrees C (86 degrees F). Get rid of any unused medicine after the expiration date.
To get rid of medicines that are no longer needed or have expired:

-Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, empty the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.