Warnings


What may interact with EPIDIOLEX?

This medicine may interact with the following medications:

-alcohol
-antihistamines for allergy, cough and cold
-caffeine
-certain medicines for anxiety or sleep
-certain medicines for depression, like amitriptyline, bupropion, fluoxetine, sertraline
-certain medicines for seizures like clobazam, lamotrigine, phenobarbital, phenytoin, primidone, stiripentol, valproate
-diflunisal
-efavirenz
-fenofibrate
-gemfibrozil
-general anesthetics like halothane, isoflurane, methoxyflurane, propofol
-local anesthetics like lidocaine, pramoxine, tetracaine
-medicines that relax muscles for surgery
-narcotic medicines for pain
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
-theophylline

What should I tell my health care provider before I take EPIDIOLEX?

They need to know if you have any of these conditions:

-liver disease
-mental illness
-suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
-an unusual or allergic reaction to cannabidiol, sesame seed oil, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

What should I watch for while using EPIDIOLEX?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effects of this medicine. Avoid alcoholic drinks.
Patients and their families should watch out for new or worsening depression or thoughts of suicide. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, call your health care professional.

Where should I keep my medicine?

Keep out of the reach of children.
This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law. Follow the directions in the MedGuide.
This medicine may cause harm and death if it is taken by other adults, children, or pets. Return medicine that has not been used to an official disposal site. Contact the DEA at 1-800-882-9539 or your city/county government to find a site. If you cannot return the medicine, mix any unused medicine with a substance like cat litter or coffee grounds. Then throw the medicine away in a sealed container like a sealed bag or coffee can with a lid. Do not use the medicine after the expiration date.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep this medicine in the original container. Throw away any unused medicine after 12 weeks.