Do not take this medicine with any of the following medications:

-artemether
-certain antivirals for HIV or hepatitis like atazanavir, daclatasvir, doravirine, elbasvir; grazoprevir, fostemsavir, lopinavir, nelfinavir, paritaprevir, rilpivirine, ritonavir, and tipranavir
-certain medicines for fungal infections like isavuconazonium and voriconazole
-lorlatinib
-lurasidone
-praziquantel
-ranolazine
This medicine may interact with the following medications:

-gemfibrozil
-certain medicines for fungal infections like ketoconazole and itraconazole
-fexofenadine
-midazolam
-omeprazole
-rosuvastatin
-warfarin

They need to know if you have any of these conditions:

-bone problems
-brain tumor
-diabetes
-head injury
-heart disease
-high blood pressure
-high cholesterol
-history of stroke
-seizures
-an unusual or allergic reaction to apalutamide, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

This medicine should not be used in women. Men should not father a child while taking this medicine and for 3 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.
Due to a risk of seizures, use caution when engaging in activities that could result in serious harm to yourself or others if you pass out.

Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.