Do not take this medicine with any of the following medications:

-narcotic medicines for cough
-sodium oxybate

This medicine may also interact with the following medications:

-alcohol
-antihistamines for allergy, cough and cold
-certain medicines for anxiety or sleep
-certain medicines for depression, like amitriptyline, fluoxetine, sertraline
-certain medicines for fungal infections like ketoconazole and itraconazole
-certain medicines for seizures like carbamazepine, phenobarbital, primidone
-general anesthetics like lidocaine, pramoxine, tetracaine
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-medicines that relax muscles for surgery
-narcotic medicines for pain
-phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

They need to know if you have any of these conditions:

-glaucoma
-history of drug or alcohol abuse problem
-kidney disease
-liver disease
-lung or breathing disease, like asthma
-mental illness
-myasthenia gravis
-Parkinson''s disease
-suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
-an unusual or allergic reaction to estazolam, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse.

Do not stop taking except on your doctor''s advice. You may develop a severe reaction. Your doctor will tell you how much medicine to take.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy and fainting spells, do not stand or sit up quickly, especially if you are an older patient. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.

If you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all medicines you use. Your doctor will tell you how much medicine to take. Do not take more medicine than directed. Call emergency for help if you have problems breathing or unusual sleepiness.

After taking this medicine, you may get up out of bed and do an activity that you do not know you are doing. The next morning, you may have no memory of this. Activities include driving a car ("sleep-driving"), making and eating food, talking on the phone, sexual activity, and sleep-walking. Serious injuries have occurred. Call your doctor right away if you find out you have done any of these activities. Do not take this medicine if you have used alcohol that evening. Do not take it if you have taken another medicine for sleep. The risk of doing these sleep-related activities is higher.

Do not take this medicine unless you are able to stay in bed for a full night (7 to 8 hours) before you must be active again. You may have a decrease in mental alertness the day after use, even if you feel that you are fully awake. Tell your doctor if you will need to perform activities requiring full alertness, such as driving, the next day. Do not stand or sit up quickly after taking this medicine, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

If you or your family notice any changes in your behavior, such as new or worsening depression, thoughts of harming yourself, anxiety, other unusual or disturbing thoughts, or memory loss, call your doctor right away.

After you stop taking this medicine, you may have trouble falling asleep. This is called rebound insomnia. This problem usually goes away on its own after 1 or 2 nights.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.

This medicine may cause accidental overdose and death if taken by other adults, children, or pets. Mix any unused medicine with a substance like cat litter or coffee grounds. Then throw the medicine away in a sealed container like a sealed bag or a coffee can with a lid. Do not use the medicine after the expiration date.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Keep container tightly closed.