What are estradiol side effects?

The most common side effects of estradiol include: 

• Headache
• Breast tenderness or breast pain
• Unusual vaginal bleeding or spotting in between menstrual periods 
• Upset stomach, stomach cramps, nausea, vomiting, diarrhea, constipation
• Vaginal swelling, redness, itching, or burning
• Hair loss
• Unwanted hair growth
• Darkening of the skin in spots
• Weight gain
• Depression
• Nervousness
• Changes in sexual desire
• Difficulty wearing contact lenses 

Tell your doctor if these side effects are severe or do not get better over time. Some side effects of estradiol are more serious. You should call your doctor immediately if you experience the following signs and symptoms:

• Bulging eyes
• Fever, chills, sore throat, cough, or other signs of infection
• Stomach pain, tenderness, or swelling
• Loss of appetite
• Weakness
• Joint pain
• Yellowing of the skin or eyes
• Difficulty controlling movements
• Hives, rash, blisters, itching
• Swelling of the face, tongue, throat, hands, or feet
• Difficulty breathing or swallowing

The above list may not include all the potential adverse effects of estradiol. Contact your doctor if you have severe adverse effects or your symptoms are worsening. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Estradiol Overdose: In case of a known or suspected overdose, get emergency medical help right away. Symptoms of an overdose of estradiol can include upset stomach, vomiting, and unusual vaginal bleeding. 

NOTE: Estradiol is a prescription drug to be used only by you. Never share it with others or use someone else’s medication.

Source: FDA