Do not take this medicine with any of the following:

-antiviral medicines for HIV or AIDS
-certain antibiotics like clarithromycin, erythromycin, telithromycin
-certain medicines for fungal infections like ketoconazole, itraconazole, posaconazole, voriconazole
-conivaptan
-cyclosporine
-danazol
-gemfibrozil
-idelalisib
-mifepristone, RU-486
-nefazodone
-supplements like red yeast rice
This medicine may also interact with the following medications:

-alcohol
-certain medicines for blood pressure or heart disease like amlodipine, diltiazem, verapamil
-certain medicines for irregular heart beat like amiodarone and dronedarone
-certain medicines that treat or prevent blood clots like warfarin
-colchicine
-digoxin
-grapefruit juice
-lomitapide
-niacin
-ranolazine

They need to know if you have any of these conditions:

-diabetes
-frequently drink alcoholic beverages
-kidney or liver disease
-muscle aches or weakness
-an unusual or allergic reaction to ezetimibe, simvastatin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor or healthcare provider for regular check-ups. You may need regular tests to make sure your liver is working properly.

Tell your doctor or healthcare provider right away if you get any unexplained muscle pain, tenderness, or weakness, especially if you also have a fever and tiredness. Your doctor or healthcare provider may tell you to stop taking this medicine if you develop muscle problems. If your muscle problems do not go away after stopping this medicine, contact your health care professional.

This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.

This drug is only part of a total heart-health program. Your doctor or a dietician can suggest a low-cholesterol and low-fat diet to help. Avoid alcohol and smoking, and keep a proper exercise schedule.

Do not use this drug if you are pregnant or breast-feeding. Serious side effects to an unborn child or to an infant are possible. Talk to your doctor or pharmacist for more information.

If you are going to have surgery tell your healthcare provider that you are taking this drug.

Some drugs may increase the risk of side effects from this medicine. If you are given certain antibiotics or antifungals, your doctor or healthcare provider may stop this medicine for a short time. Check with your doctor or pharmacist for advice.

This medicine may cause a decrease in Co-Enzyme Q-10. You should make sure that you get enough Co-Enzyme Q-10 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your healthcare provider.

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.