Do not take this medicine with any of the following medications:

-antiviral medicines for HIV or AIDS
-certain antibiotics like clarithromycin, erythromycin, telithromycin
-certain medicines for fungal infections like ketoconazole, itraconazole, posaconazole, voriconazole
-conivaptan
-cyclosporine
-danazol
-gemfibrozil
-idelalisib
-mifepristone, RU-486
-nefazodone
-supplements like red yeast rice
This medicine may also interact with the following medications:

-alcohol
-certain medicines for blood pressure or heart disease like amlodipine, diltiazem, verapamil
-certain medicines for irregular heart beat like amiodarone and dronedarone
-certain medicines that treat or prevent blood clots like warfarin
-colchicine
-digoxin
-grapefruit juice
-lomitapide
-niacin
-ranolazine

They need to know if you have any of these conditions:

-diabetes
-frequently drink alcoholic beverages
-kidney disease
-liver disease
-muscle aches or weakness
-an unusual allergic reaction to simvastatin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

You may blood work done while taking this medicine.
Your doctor or health care professional may tell you to stop taking this medicine if you develop muscle problems. If your muscle problems do not go away after stopping this medicine, contact your health care professional.
This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.
Do not use this drug if you are pregnant or breast-feeding. Serious side effects to an unborn child or to an infant are possible. Talk to your doctor or pharmacist for more information.
This medicine may cause a decrease in Co-Enzyme Q-10. You should make sure that you get enough Co-Enzyme Q-10 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 to 77 degrees F). Keep container tightly closed. Use within 30 days of opening the bottle. Throw away any unused medicine after the expiration date.