Fosfomycin Tromethamine

Medically Reviewed by Dr. Harshi Dhingra, M.D.

Last Reviewed: Aug 08, 2024

Warnings

Fosfomycin Tromethamine (Monurol) Risks, Warnings, and Complications

Fosfomycin tromethamine can cause or worsen health problems in some people. Talk to your doctor or pharmacist about other treatment options for urinary tract infections if you are at an increased risk of adverse effects from this medication. Some of the risks of taking fosfomycin tromethamine include:

CLOSTRIDIUM DIFFICILE ASSOCIATED DIARRHEA: Nearly all antibacterial agents, including fosfomycin tromethamine, can cause a severe intestinal condition called Clostridium difficile associated diarrhea (CDAD). This can range in severity from mild diarrhea to life-threatening colitis. CDAD occurs due to the overgrowth of a bacteria called Clostridium difficile when the gut microbiome is disrupted by antibiotic treatment. Symptoms may include bloody or watery diarrhea with or without stomach cramps and fever. CDAD can occur up to 2 months or more after taking antibiotics. Tell your health care professional immediately or seek medical attention if you develop these serious symptoms.

Precautions Before Starting Fosfomycin Tromethamine (Monurol)

Tell your doctor if you have ever had allergic reactions to fosfomycin tromethamine, any of the active or inactive ingredients in fosfomycin tromethamine granules or powder, other antibiotics, or any other drugs. Your pharmacy can give you a list of ingredients.

Give your doctor and pharmacist a complete list of your other medicines, including prescription drugs, nonprescription drugs, dietary supplements, and herbal products. This can help avoid potentially dangerous interactions between your medications.

Give your healthcare provider a complete medical history. Fosfomycin tromethamine may not be safe for people with certain medical conditions, such as asthma, liver disease, or kidney disease.

Taking Monurol may not be safe for pregnant women. Tell your doctor if you are pregnant, could be pregnant, are planning a pregnancy soon. They will prescribe this antibiotic if the potential benefits outweigh the risks. Also tell your healthcare professional if you are breast-feeding. It is unclear if the drug passes into breast milk.

Precautions During Use of Fosfomycin Tromethamine (Monurol)

Keep all your medical and lab appointments while on fosfomycin tromethamine. Tell your doctor if your UTI symptoms do not improve after a single dose of antibiotic.

Call your doctor if you become pregnant while taking fosfomycin tromethamine.

Other precautions include telling all your doctors you are on fosfomycin tromethamine, especially before any procedures, including dental treatments.

Fosfomycin Tromethamine (Monurol) Drug Interactions

Certain other drugs can affect how fosfomycin tromethamine works. Possible drug interactions between fosfomycin tromethamine and other medicines can increase the risk of severe adverse effects. The following medications can have interactions with fosfomycin tromethamine:

Medications prescribed for gastroesophageal reflux disease (GERD), such as cisapride (Propulsid) and metoclopramide (Reglan)
Vitamins
Cholera vaccine

The above list does not include all possible interactions of fosfomycin tromethamine. Give your doctor or pharmacist a complete list of your medications, including prescription drugs, nonprescription drugs, dietary supplements, and herbal products. Also, tell your healthcare professional if you smoke, drink alcohol, or use recreational drugs because some of these substances can cause serious health complications when used with prescription medications.

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