-amiodarone
-carbamazepine
-certain medicines for fungal infections like ketoconazole and itraconazole
-cyclosporine A
-erythromycin
-grapefruit juice
-nelfinavir
-phenobarbital
-phenytoin
-quinidine
-rifampicin
-ritonavir
-saquinavir
-St. John''s wort
-tacrolimus
-verapamil

They need to know if you have any of these conditions:

-eye disease, vision problems, or if you wear contact lenses
-heart disease
-kidney disease
-liver disease
-lung or breathing disease
-stomach or intestine problems
-an unusual or allergic reaction to afatinib, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your doctor for regular check ups. Report any side effects. Continue your course of treatment unless your doctor tells you to stop. You will need blood work done while you are taking this medicine.

If you experience any of the following, contact your healthcare provider: eye irritation; rash; severe or continuing diarrhea, nausea, decreased appetite, or vomiting; or if your breathing gets worse or you develop shortness of breath or cough.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your healthcare provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

Do not become pregnant while taking this medicine or for 2 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your healthcare provider or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after the last dose.

Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.