Do not take this medicine with any of the following medications:

-certain medicines for erectile dysfunction like avanafil, sildenafil, tadalafil, and vardenafil
-ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
-riociguat
This medicine may also interact with the following medications:

-certain medicines for blood pressure

They need to know if you have any of these conditions:

-anemia
-bleeding in the brain
-head injury
-heart disease
-liver disease
-an unusual or allergic reaction to nitroglycerin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Tell your doctor or health care professional if your symptoms do not start to get better or if you feel worse.

Keep this medicine with you at all times. Sit down when you take your medicine to prevent falling if you feel dizzy or faint after using it. Try to remain calm. This will help you to feel better faster. If you feel dizzy, take several deep breaths and lie down with your feet propped up, or bend forward with your head resting between your knees.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

Keep out of the reach of children.

Store between 5 and 40 degrees C (41 and 104 degrees F). Throw away any unused medicine after the expiration date.