Do not take this medicine with any of the following medications:

-aspirin and aspirin-like drugs
-mifepristone
-medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
-palifermin
-protamine

This medicine may also interact with the following medications:

-dextran
-digoxin
-hydroxychloroquine
-medicines for treating colds or allergies
-nicotine
-NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
-phenylbutazone
-tetracycline antibiotics

They need to know if you have any of these conditions:
-bleeding disorders, such as hemophilia or low blood platelets
-bowel disease or diverticulitis
-endocarditis
-high blood pressure
-liver disease
-recent surgery or delivery of a baby
-stomach ulcers
-an unusual or allergic reaction to heparin, benzyl alcohol, sulfites, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your healthcare professional for regular checks on your progress. You may need blood work done while you are taking this medicine. Your condition will be monitored carefully while you are receiving this medicine. It is important not to miss any appointments.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.


Notify your doctor or healthcare professional at once if you have cold, blue hands or feet.

If you are going to need surgery or other procedure, tell your healthcare professional that you are using this medicine.

Avoid sports and activities that might cause injury while you are using this medicine. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your healthcare professional.

Using this medicine for a long time may weaken your bones and increase the risk of bone fractures.

You should make sure that you get enough calcium and vitamin D while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your healthcare professional.

Wear a medical ID bracelet or chain. Carry a card that describes your disease and details of your medicine and dosage times.

Keep out of the reach of children.

Store unopened vials at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Do not use if solution is discolored or particulate matter is present. Throw away any unused medicine after the expiration date.