Hydrocodone-Homatropine (Hycodan) Side Effects

Possible side effects of hydrocodone and homatropine are listed below. Call your doctor for medical advice about side effects if they are severe or persist after a few days.

• Drowsiness
• Dizziness or lightheadedness
• Reduced mental alertness
• Lack of energy
• Dry mouth
• Nasal congestion
• Headache
• Nausea
• Vomiting
• Constipation

Some of the adverse effects of hydrocodone and homatropine are more serious. Call your doctor right away or seek emergency medical help if you develop the following serious symptoms:

• Slow or irregular breathing
• Chest pain or chest tightness
• Confusion, agitation, hallucinations, fever, sweating, shivering, fast heartbeat, severe muscle stiffness or muscle twitching, loss of coordination
• Weakness, dizziness, nausea, vomiting, diarrhea, loss of appetite
• Erectile dysfunction 
• Irregular menstruation
• Decreased libido (sexual desire)
• An unusual or allergic reaction with skin rash, hives, itching, or swelling

The above list may not include all the potential side effects of hydrocodone and homatropine. Contact your healthcare provider if your side effects are unusual or severe or they do not get better over time. You can also report unusual side effects to the Food and Drug Administration at 1-800-FDA-1088.

Hydrocodone-homatropine (Hycodan) Overdose: In case of an overdose of hydrocodone and homatropine, call your doctor immediately. You can also call your local poison control center, provincial poison control center, or the national poison control center at 1-800-222-1222. Overdose symptoms may include slowed, shallow, or stopped breathing, slow heartbeat, excessive drowsiness, narrowed or widened pupils, cold, clammy skin, unresponsiveness, and seizures.

Hydrocodone is an opioid and can cause dose-related respiratory depression. If you take hydrocodone-containing products regularly, talk to your healthcare provider about having an opioid antagonist called naloxone (Narcan) available. This rescue medication can reverse the potentially fatal effects of an opioid overdose.

Source: FDA