Do not take this medicine with any of the following medications:

-defibrotide
This medicine may also interact with the following medications:

-acyclovir
-allopurinol
-aprepitant
-armodafinil
-aspirin
-bicalutamide
-bosentan
-caffeine
-capecitabine
-certain antibiotics like erythromycin, clarithromycin, ciprofloxacin, cotrimoxazole, metronidazole, norfloxacin, or tigecycline
-certain antivirals for HIV or hepatitis
-certain medicines for blood clots like argatroban, aspirin, bivalirudin, enoxaparin, fondaparinux, heparin, or lepirudin
-certain medicines for blood pressure, heart disease, irregular heart beat
-certain medicines for cholesterol like atorvastatin, lovastatin, and simvastatin
-certain medicines for depression, anxiety, or psychiatric disorders
-certain medicines for fungal infections like fluconazole, ketoconazole, itraconazole, posaconazole, or voriconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin, rufinamide
-cilostazol
-clopidogrel
-conivaptan
-cyclosporine
-dipyridamole
-disulfiram
-female hormones, including contraceptive or birth control pills
-herbal or dietary products like garlic, ginkgo, ginseng, green tea, kava kava, red yeast rice, St. Johns Wort
-isoniazid
-methoxsalen
-modafinil
-nilotinib
-NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
-oxandrolone
-phenylpropanolamine
-prasugrel
-rifampin
-steroid medicines like prednisone or cortisone
-stomach acid blockers like cimetidine, famotidine, ranitidine, or omeprazole
-sulfinpyrazone
-thiabendazole
-ticlopidine
-vitamin K
-zafirlukast
-zileutin

They need to know if you have any of these conditions:

-alcoholism
-anemia
-bleeding disorders
-cancer
-diabetes
-heart disease
-high blood pressure
-history of bleeding in the gastrointestinal tract
-history of stroke or other brain injury or disease
-kidney or liver disease
-protein C deficiency
-protein S deficiency
-psychosis or dementia
-recent injury, recent or planned surgery or procedure
-an unusual or allergic reaction to warfarin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

Visit your healthcare professional for regular checks on your progress. You will need to have a blood test called a PT/INR regularly. The PT/INR blood test is done to make sure you are getting the right dose of this medicine. It is important to not miss your appointment for the blood tests. When you first start taking this medicine, these tests are done often. Once the correct dose is determined and you take your medicine properly, these tests can be done less often.
Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.
Do not start taking or stop taking any medicines or over-the-counter medicines except on the advice of your healthcare professional.
You should discuss your diet with your healthcare professional. Do not make major changes in your diet. Vitamin K can affect how well this medicine works. Many foods contain vitamin K. It is important to eat a consistent amount of foods with vitamin K. Other foods with vitamin K that you should eat in consistent amounts are asparagus, basil, black-eyed peas, broccoli, brussel sprouts, cabbage, green onions, green tea, parsley, green leafy vegetables like beet greens, collard greens, kale, spinach, turnip greens, or certain lettuces like green leaf or romaine.
This medicine can cause birth defects or bleeding in an unborn child. Women of childbearing age should use effective birth control while taking this medicine. If a woman becomes pregnant while taking this medicine, she should discuss the potential risks and her options with her healthcare professional.
Avoid sports and activities that might cause injury while you are using this medicine. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your healthcare professional.
If you have an illness that causes vomiting, diarrhea, or fever for more than a few days, contact your health care professional. Also, check with your healthcare professional if you are unable to eat for several days. These problems can change the effect of this medicine.
Even after you stop taking this medicine, it takes several days before your body recovers its normal ability to clot blood. Ask your healthcare professional how long you need to be careful. If you are going to have surgery or dental work, tell your health care professional that you have been taking this medicine.

Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date. Do not flush down the toilet.